The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway (Q28118993)

4 January 2017

title

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway (English)

1 reference

Cytosolic arginine sensor for mTORC1 subunit 2

4 January 2017

main subject

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Cytosolic arginine sensor for mTORC1 subunit 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

9

Steven P. Gygi

1 reference

4 January 2017

10

David M. Sabatini

1 reference

4 January 2017

8

J. Wade Harper

1 reference

4 January 2017

Lynne Chantranupong

1

1 reference

4 January 2017

Sonia M. Scaria

2

1 reference

4 January 2017

Robert A. Saxton

3

1 reference

4 January 2017

Melanie P. Gygi

4

1 reference

4 January 2017

Kuang Shen

5

1 reference

4 January 2017

Gregory A. Wyant

6

1 reference

4 January 2017

Tim Wang

7

1 reference

4 January 2017

language of work or name

English

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publication date

24 March 2016

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4 January 2017

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4 January 2017

volume

165

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4 January 2017

issue

1

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4 January 2017

page(s)

153–164

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Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

4 January 2017

cites work

1 reference

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

20 March 2017

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

20 March 2017

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

20 March 2017

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Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

20 March 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

20 March 2017

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20 March 2017

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FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

20 March 2017

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Amino acids and mTORC1: from lysosomes to disease

20 March 2017

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20 March 2017

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20 March 2017

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Tyrosine Latching of a Regulatory Gate Affords Allosteric Control of Aromatic Amino Acid Biosynthesis

20 March 2017

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Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain

20 March 2017

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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

20 March 2017

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

20 March 2017

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Sestrins inhibit mTORC1 kinase activation through the GATOR complex

20 March 2017

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Sestrin2 is a leucine sensor for the mTORC1 pathway

20 March 2017

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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

20 March 2017

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

20 March 2017

1 reference

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Localization of Rheb to the endomembrane is critical for its signaling function

20 March 2017

1 reference

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

20 March 2017

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Role of mTOR signaling in intestinal cell migration

20 March 2017

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

20 March 2017

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 April 2017

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7 April 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

29 September 2017

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Novel Foxo1-dependent transcriptional programs control T(reg) cell function

29 September 2017

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The many faces of aspartate kinases

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

29 September 2017

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Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

2 June 2018

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Structural features of the regulatory ACT domain of phenylalanine hydroxylase

2 June 2018

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2 June 2018

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27 November 2018

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Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

27 November 2018

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12 December 2020

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12 December 2020