The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases (Q28139237)

Europe PubMed Central

title

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases (English)

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author name string

P K Jackson

1

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A G Eldridge

2

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E Freed

3

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L Furstenthal

4

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J Y Hsu

5

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B K Kaiser

6

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J D Reimann

SCF and Cullin/Ring H2-based ubiquitin ligases

7

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language of work or name

English

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publication date

October 2000

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published in

Trends in Cell Biology

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volume

10

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issue

10

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page(s)

429-39

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cites work

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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Identification of a family of human F-box proteins

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Identification of novel F-box proteins in Xenopus laevis

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A family of mammalian F-box proteins

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

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7 January 2021

F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p

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7 January 2021

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination

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Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase

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Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism

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The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skp1p

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7 January 2021

Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

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The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex

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7 January 2021

Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation

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7 January 2021

The VHL tumour-suppressor gene paradigm

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

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Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

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Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

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Cell cycle: oiling the gears of anaphase

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Identification of a cullin homology region in a subunit of the anaphase-promoting complex

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Identification of human APC10/Doc1 as a subunit of anaphase promoting complex

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Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex

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Cyclin is degraded by the ubiquitin pathway

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Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.

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Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

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7 January 2021

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

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7 January 2021

Control of mitotic transitions by the anaphase-promoting complex

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7 January 2021

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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7 January 2021

RING domains: master builders of molecular scaffolds?

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7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

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7 January 2021

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

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7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

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7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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7 January 2021

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

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7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

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7 January 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

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7 January 2021

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

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7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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7 January 2021

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

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7 January 2021

Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases

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7 January 2021

The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction

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7 January 2021

Ubiquitin-like proteins: new wines in new bottles

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7 January 2021

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

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7 January 2021

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

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7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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7 January 2021

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

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7 January 2021

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

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7 January 2021

10.1016/S0962-8924(00)01834-1

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

10998601

1 reference

Consolidated OpenCitations Corpus – April 2017