Biochemistry and molecular cell biology of diabetic complications (Q28131781)

7 January 2021

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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7 January 2021

Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study

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7 January 2021

Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

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7 January 2021

Insulin resistance and cardiovascular disease

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7 January 2021

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7 January 2021

Cardiovascular risk continuum: implications of insulin resistance and diabetes.

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7 January 2021

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

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7 January 2021

Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo

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7 January 2021

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

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7 January 2021

Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level

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7 January 2021

An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications

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7 January 2021

Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2

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7 January 2021

Hyperglycemic pseudohypoxia and diabetic complications.

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7 January 2021

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

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7 January 2021

Contributions of polyol pathway to oxidative stress in diabetic cataract.

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7 January 2021

Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs

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7 January 2021

Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group

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7 January 2021

Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy

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7 January 2021

Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose

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7 January 2021

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

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7 January 2021

Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone

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7 January 2021

Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat

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7 January 2021

Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation

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7 January 2021

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

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7 January 2021

Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes

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7 January 2021

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

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7 January 2021

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

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7 January 2021

Glycation induces expansion of the molecular packing of collagen

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7 January 2021

Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats

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7 January 2021

Laminin alterations after in vitro nonenzymatic glycosylation

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7 January 2021

Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth

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7 January 2021

Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

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7 January 2021

Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells

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7 January 2021

Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling

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7 January 2021

Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins

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7 January 2021

Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts

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7 January 2021

Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy

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7 January 2021

Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor

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7 January 2021

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of dia

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7 January 2021

Advanced glycation end products increase retinal vascular endothelial growth factor expression

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7 January 2021

Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

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7 January 2021

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

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7 January 2021

Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells

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7 January 2021

Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial cells

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7 January 2021

Protein kinase C activation and the development of diabetic complications

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7 January 2021

Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia

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7 January 2021

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

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7 January 2021

Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure

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7 January 2021

Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation

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7 January 2021

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

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7 January 2021

Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response

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7 January 2021

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

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7 January 2021

High glucose alters the response of mesangial cell protein kinase C isoforms to endothelin-1.

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7 January 2021

High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha

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7 January 2021

Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro

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7 January 2021

Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium

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7 January 2021

Nitric oxide inhibition of transforming growth factor-beta and collagen synthesis in mesangial cells

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7 January 2021

Regulation of the laminin C1 promoter in cultured mesangial cells

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7 January 2021

Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression

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7 January 2021

Activation of nuclear factor-kappaB in cultured endothelial cells by increased glucose concentration: prevention by calphostin C

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7 January 2021

Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells

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7 January 2021

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

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7 January 2021

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells

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7 January 2021

Role of the glucosamine pathway in fat-induced insulin resistance

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7 January 2021

Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells

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7 January 2021

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells

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7 January 2021

Distinct regions of Sp1 modulate DNA binding and transcriptional activation

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7 January 2021

Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

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7 January 2021

Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins

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7 January 2021

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

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7 January 2021

Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens

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7 January 2021

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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7 January 2021

Oxidative stress and diabetic vascular complications

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7 January 2021

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells

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7 January 2021

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

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7 January 2021

Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction

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7 January 2021

Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice

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7 January 2021

Progression of incipient diabetic retinopathy during good glycemic control.

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7 January 2021

Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy

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7 January 2021

Familial aggregation of coronary artery calcium in families with type 2 diabetes

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7 January 2021

Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy

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7 January 2021

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

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7 January 2021

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators

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7 January 2021

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

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7 January 2021

Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve

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7 January 2021