RNA interference (Q28131798)

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Europe PubMed Central

title

RNA interference (English)

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1

Gregory J Hannon

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language of work or name

English

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publication date

11 July 2002

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published in

Nature

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volume

418

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issue

6894

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page(s)

244-51

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cites work

1 reference

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

21 April 2017

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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

21 April 2017

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A species of small antisense RNA in posttranscriptional gene silencing in plants

21 April 2017

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 April 2017

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A novel type of RNase III family proteins in eukaryotes

21 April 2017

1 reference

Role for a bidentate ribonuclease in the initiation step of RNA interference

21 April 2017

1 reference

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

21 April 2017

1 reference

Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage

21 April 2017

1 reference

Post-transcriptional gene silencing by double-stranded RNA

21 April 2017

1 reference

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

21 April 2017

1 reference

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

21 April 2017

1 reference

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

21 April 2017

1 reference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 April 2017

1 reference

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 April 2017

1 reference

Identification of novel genes coding for small expressed RNAs

21 April 2017

1 reference

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

21 April 2017

1 reference

An extensive class of small RNAs in Caenorhabditis elegans

21 April 2017

1 reference

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

21 April 2017

1 reference

Stable suppression of gene expression by RNAi in mammalian cells

21 April 2017

1 reference

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 April 2017

1 reference

Specific interference by ingested dsRNA

21 April 2017

1 reference

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

21 April 2017

1 reference

Argonaute2, a link between genetic and biochemical analyses of RNAi

21 April 2017

1 reference

Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation

21 April 2017

1 reference

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

21 April 2017

1 reference

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

21 April 2017

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7 January 2021

Inhibition of flower pigmentation by antisense CHS genes: promoter and minimal sequence requirements for the antisense effect

1 reference

7 January 2021

Altered gene expression in plants due to trans interactions between homologous genes

1 reference

7 January 2021

Chalcone synthase cosuppression phenotypes in petunia flowers: comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences

1 reference

7 January 2021

The Frequency and Degree of Cosuppression by Sense Chalcone Synthase Transgenes Are Dependent on Transgene Promoter Strength and Are Reduced by Premature Nonsense Codons in the Transgene Coding Sequence.

1 reference

7 January 2021

Initiation and maintenance of virus-induced gene silencing

1 reference

7 January 2021

Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA.

1 reference

7 January 2021

Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA

1 reference

7 January 2021

Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences

1 reference

7 January 2021

Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent

1 reference

7 January 2021

An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus

1 reference

7 January 2021

RNA-directed transcriptional gene silencing in plants can be inherited independently of the RNA trigger and requires Met1 for maintenance

1 reference

7 January 2021

RNA-directed de novo methylation of genomic sequences in plants.

1 reference

7 January 2021

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

1 reference

7 January 2021

1 reference

7 January 2021

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

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7 January 2021

Using RNA interference to identify genes required for RNA interference

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7 January 2021

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1 reference

7 January 2021

Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.

1 reference

7 January 2021

Targeted mRNA degradation by double-stranded RNA in vitro

1 reference

7 January 2021

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

1 reference

7 January 2021

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

1 reference

7 January 2021

ATP requirements and small interfering RNA structure in the RNA interference pathway

1 reference

7 January 2021

AGO1 defines a novel locus of Arabidopsis controlling leaf development.

1 reference

7 January 2021

Genetic requirements for inheritance of RNAi in C. elegans

1 reference

7 January 2021

Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

1 reference

7 January 2021

Involvement of small RNAs and role of the qde genes in the gene silencing pathway in Neurospora

1 reference

7 January 2021

On the role of RNA amplification in dsRNA-triggered gene silencing

1 reference

7 January 2021

Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance

1 reference

7 January 2021

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

1 reference

7 January 2021

1 reference

7 January 2021

RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs.

1 reference

7 January 2021

Spreading of RNA targeting and DNA methylation in RNA silencing requires transcription of the target gene and a putative RNA-dependent RNA polymerase

1 reference

7 January 2021

Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA.

1 reference

7 January 2021

Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.

1 reference

7 January 2021

Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase

1 reference

7 January 2021

Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase

1 reference

7 January 2021

RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs

1 reference

7 January 2021

A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans

1 reference

7 January 2021

DNA methylation and epigenetic inheritance in plants and filamentous fungi

1 reference

7 January 2021

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

1 reference

7 January 2021

A viral movement protein prevents spread of the gene silencing signal in Nicotiana benthamiana

1 reference

7 January 2021

Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily.

1 reference

7 January 2021

A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal

1 reference

7 January 2021

Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance

1 reference

7 January 2021

Role of the ZWILLE gene in the regulation of central shoot meristem cell fate during Arabidopsis embryogenesis

1 reference

7 January 2021

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1 reference

7 January 2021

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

1 reference

7 January 2021

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation

1 reference

7 January 2021

Specific interference with gene function by double-stranded RNA in early mouse development

1 reference

7 January 2021

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

1 reference

7 January 2021

Total silencing by intron-spliced hairpin RNAs

1 reference

7 January 2021

Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes

1 reference

7 January 2021

Heritable gene silencing in Drosophila using double-stranded RNA.

1 reference

7 January 2021

Double-stranded RNA interference in Trypanosoma brucei using head-to-head promoters

1 reference

7 January 2021

Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA.

1 reference

7 January 2021

Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters

1 reference

7 January 2021

Development of an inducible pol III transcription system essentially requiring a mutated form of the TATA-binding protein

1 reference

7 January 2021

Control of the functional activity of an antisense RNA by a tetracycline-responsive derivative of the human U6 snRNA promoter

1 reference

7 January 2021