The transcriptional role of PML and the nuclear body (Q28144176)

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

Europe PubMed Central

title

The transcriptional role of PML and the nuclear body (English)

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author name string

S Zhong

series ordinal

1

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P Salomoni

series ordinal

2

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P P Pandolfi

series ordinal

3

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language of work or name

English

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publication date

May 2000

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published in

Nature Cell Biology

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volume

2

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issue

5

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page(s)

E85-90

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cites work

1 reference

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

21 January 2018

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

21 January 2018

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In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications

21 January 2018

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Nuclear dots: actors on many stages

21 January 2018

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Identification of a novel nuclear domain

21 January 2018

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

21 January 2018

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Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

21 January 2018

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Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies.

21 January 2018

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Nuclear domain 10, the site of DNA virus transcription and replication

21 January 2018

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21 January 2018

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Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

21 January 2018

1 reference

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

21 January 2018

1 reference

A role for PML and the nuclear body in genomic stability

21 January 2018

1 reference

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis

21 January 2018

1 reference

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

21 January 2018

1 reference

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

21 January 2018

1 reference

Identification of three major sentrinization sites in PML

21 January 2018

1 reference

SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex

21 January 2018

1 reference

Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3

21 January 2018

1 reference

Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1

21 January 2018

1 reference

The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers

21 January 2018

1 reference

A new protease required for cell-cycle progression in yeast

21 January 2018

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Differential regulation of sentrinized proteins by a novel sentrin-specific protease

21 January 2018

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A novel cysteine-rich sequence motif

21 January 2018

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The RING finger domain: a recent example of a sequence-structure family

21 January 2018

1 reference

Acute promyelocytic leukemia as a model for cross-talk between interferon and retinoic acid pathways: from molecular biology to clinical applications.

21 January 2018

1 reference

The periphery of nuclear domain 10 (ND10) as site of DNA virus deposition

21 January 2018

1 reference

A viral activator of gene expression functions via the ubiquitin-proteasome pathway

21 January 2018

1 reference

Molecular cloning of a new interferon-induced PML nuclear body-associated protein

21 January 2018

1 reference

Role of PML in cell growth and the retinoic acid pathway

21 January 2018

1 reference

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

21 January 2018

1 reference

The promyelocytic leukemia protein PML has a pro-apoptotic activity mediated through its RING domain

21 January 2018

1 reference

PML induces a novel caspase-independent death process

21 January 2018

1 reference

Cooperation between the RING + B1-B2 and coiled-coil domains of PML is necessary for its effects on cell survival.

21 January 2018

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Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

21 January 2018

1 reference

Sequestration and inhibition of Daxx-mediated transcriptional repression by PML

21 January 2018

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PML, a growth suppressor disrupted in acute promyelocytic leukemia

21 January 2018

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Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML.

21 January 2018

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The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

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Molecular genetics of Bloom's syndrome

21 January 2018

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

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Insights into the functions of BRCA1 and BRCA2.

21 January 2018

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Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML

21 January 2018

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Transcriptional repression by the promyelocytic leukemia protein, PML.

21 January 2018

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Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

21 January 2018

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Composite co-activator ARC mediates chromatin-directed transcriptional activation

21 January 2018

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Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex

21 January 2018

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A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins

21 January 2018

1 reference

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

21 January 2018

1 reference

Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein

21 January 2018

1 reference

The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter

21 January 2018

1 reference

Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling

21 January 2018

1 reference

Intranuclear redistribution of SV40T, p53, and PML in a conditionally SV40T-immortalized cell line

21 January 2018

1 reference

An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

1 reference

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

1 reference

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

Role of CBP/P300 in nuclear receptor signalling

21 January 2018

1 reference

The CBP co-activator is a histone acetyltransferase

21 January 2018

1 reference

Regulation of activity of the transcription factor GATA-1 by acetylation

21 January 2018

1 reference

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

21 January 2018

1 reference

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

21 January 2018

1 reference

The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome

21 January 2018

1 reference

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

21 January 2018

1 reference

Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

21 January 2018

1 reference

Identification and characterization of a leukocyte-specific component of the nuclear body

21 January 2018

1 reference

Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA

21 January 2018

1 reference

Chromatin components as part of a putative transcriptional repressing complex

21 January 2018

1 reference

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR

21 January 2018

1 reference

7 January 2021

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML

1 reference

7 January 2021

Alteration of the PML proto-oncogene in leukemic cells does not abrogate expression of MHC class I antigens

1 reference

7 January 2021

PML is essential for multiple apoptotic pathways

1 reference

7 January 2021