From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels (Q28143653)

Identification of a large molecular weight peptide associated with a tetrodotoxin binding protein from the electroplax of Electrophorus electricus

Europe PubMed Central

title

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels (English)

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W A Catterall

1

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language of work or name

English

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publication date

April 2000

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published in

Neuron

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volume

26

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issue

1

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page(s)

13-25

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Sodium channels and gating currents

1 reference

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7 January 2021

Molecular localization of an ion-binding site within the pore of mammalian sodium channels

1 reference

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7 January 2021

Protein components of the purified sodium channel from rat skeletal muscle sarcolemma

1 reference

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7 January 2021

A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Covalent labeling of protein components of the sodium channel with a photoactivable derivative of scorpion toxin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular dynamics of the sodium channel pore vary with gating: interactions between P-segment motions and inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A molecular basis for gating mode transitions in human skeletal muscle Na+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular mechanism for an inherited cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: evidence for D1 receptor involvement

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Sodium channel defects in myotonia and periodic paralysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Muscarinic modulation of sodium current by activation of protein kinase C in rat hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Voltage sensor-trapping: enhanced activation of sodium channels by beta-scorpion toxin bound to the S3-S4 loop in domain II.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Modulation of Na+ channel inactivation by the beta 1 subunit: a deletion analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A unique role for the S4 segment of domain 4 in the inactivation of sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The internal quaternary ammonium receptor site of Shaker potassium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Phosphorylation of the alpha subunit of the sodium channel by protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Restoration of inactivation and block of open sodium channels by an inactivation gate peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Voltage-dependent activation in purified reconstituted sodium channels from rabbit T-tubular membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Diversity of mammalian voltage-gated sodium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Messenger RNA coding for only the alpha subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular model of the action potential sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Purification of the saxitoxin receptor of the sodium channel from rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Functional reconstitution of the purified brain sodium channel in planar lipid bilayers

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular basis for pharmacological differences between brain and cardiac sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Calcium channel characteristics conferred on the sodium channel by single mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Transfer of twelve charges is needed to open skeletal muscle Na+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A quantitative description of membrane current and its application to conduction and excitation in nerve

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Movement of the Na+ channel inactivation gate during inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular analysis of potential hinge residues in the inactivation gate of brain type IIA Na+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular analysis of the putative inactivation particle in the inactivation gate of brain type IIA Na+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The screw-helical voltage gating of ion channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Transmembrane movement of the shaker K+ channel S4.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Role in fast inactivation of the IV/S4-S5 loop of the human muscle Na+ channel probed by cysteine mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Functional modulation of brain sodium channels by cAMP-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Modulation of vertebrate brain Na+ and K+ channels by subtypes of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular determinants of beta 1 subunit-induced gating modulation in voltage-dependent Na+ channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Temperature-sensitive mutations in the III–IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The extracellular domain of the beta1 subunit is both necessary and sufficient for beta1-like modulation of sodium channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

1990: annus mirabilis of potassium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Existence of distinct sodium channel messenger RNAs in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Expression of functional sodium channels from cloned cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Functional modulation of brain sodium channels by protein kinase C phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Electrostatic interactions of S4 voltage sensor in shaker K+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Identification of a mutation in the gene causing hyperkalemic periodic paralysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Functional roles of the extracellular segments of the sodium channel alpha subunit in voltage-dependent gating and modulation by beta1 subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The binding of saxitoxin and tetrodotoxin to excitable tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Solution structure of the sodium channel inactivation gate

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A Met-to-Val mutation in the skeletal muscle Na+ channel alpha-subunit in hyperkalaemic periodic paralysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Pore properties of rat brain II sodium channels mutated in the selectivity filter domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Mechanism of modulation of single sodium channels from skeletal muscle by the beta 1-subunit from rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Interaction between the sodium channel inactivation linker and domain III S4-S5.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Identification of a phenylalkylamine binding region within the alpha 1 subunit of skeletal muscle Ca2+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Structural parts involved in activation and inactivation of the sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Identification of an intracellular peptide segment involved in sodium channel inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Inhibition of inactivation of single sodium channels by a site-directed antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

The (Greek) key to structures of neural adhesion molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

1 reference

7 January 2021

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A phosphorylation site in the Na+ channel required for modulation by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Tenascin-R is a functional modulator of sodium channel beta subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Evidence for voltage-dependent S4 movement in sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Molecular basis of charge movement in voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981133-2

7 January 2021

10.1016/S0896-6273(00)81133-2

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

10798388

1 reference

Consolidated OpenCitations Corpus – April 2017