Immunopathogenesis and immunotherapy in AIDS virus infections (Q28183667)

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

Europe PubMed Central

title

Immunopathogenesis and immunotherapy in AIDS virus infections (English)

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Bruce D Walker

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Norman L. Letvin

series ordinal

1

object named as

Norman L Letvin

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language of work or name

English

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publication date

July 2003

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published in

Nature Medicine

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volume

9

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issue

7

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page(s)

861-6

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

A role for carbohydrates in immune evasion in AIDS.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Antibody neutralization and escape by HIV-1

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Simian immunodeficiency virus-specific CD8+ lymphocyte response in acutely infected rhesus monkeys.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

T cell receptor V beta repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Immunization with a modified vaccinia virus expressing simian immunodeficiency virus (SIV) Gag-Pol primes for an anamnestic Gag-specific cytotoxic T-lymphocyte response and is associated with reduction of viremia after SIV challenge

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Prolonged dominance of clonally restricted CD4(+) T cells in macaques infected with simian immunodeficiency viruses

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Evolution and transmission of stable CTL escape mutations in HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Advantage of rare HLA supertype in HIV disease progression

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Weak anti-HIV CD8(+) T-cell effector activity in HIV primary infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

In vivo persistence of a HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specificin vitro reactivity

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HIV preferentially infects HIV-specific CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Skewed maturation of memory HIV-specific CD8 T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Potent and synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccination

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Therapeutic dendritic-cell vaccine for simian AIDS.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Immune control of HIV-1 after early treatment of acute infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Control of HIV despite the Discontinuation of Antiretroviral Therapy

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021

Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0703-861

7 January 2021