c-MYC: more than just a matter of life and death (Q28205057)

c-Myc target genes involved in cell growth, apoptosis, and metabolism

Europe PubMed Central

title

c-MYC: more than just a matter of life and death (English)

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author name string

Stella Pelengaris

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1

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Mike Khan

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2

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Gerard Evan

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3

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language of work or name

English

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publication date

October 2002

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published in

Nature Reviews Cancer

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volume

2

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issue

10

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page(s)

764-76

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cites work

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MYC oncogenes and human neoplastic disease

31 March 2020

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Influence of increased c-Myc expression on the growth characteristics of human melanoma

31 March 2020

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

31 March 2020

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Oncogenic activity of the c-Myc protein requires dimerization with Max.

31 March 2020

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The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

31 March 2020

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New Myc-interacting proteins: a second Myc network emerges

31 March 2020

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31 March 2020

Myc and the cell cycle

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Integrating Myc and TGF-beta signalling in cell-cycle control

31 March 2020

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A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice

31 March 2020

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Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos

31 March 2020

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Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc

31 March 2020

1 reference

An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc

31 March 2020

1 reference

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

31 March 2020

1 reference

Drosophila myc regulates cellular growth during development.

31 March 2020

1 reference

c-Myc enhances protein synthesis and cell size during B lymphocyte development

31 March 2020

1 reference

Control of cell growth by c-Myc in the absence of cell division

31 March 2020

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Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

31 March 2020

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Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

31 March 2020

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Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity.

31 March 2020

1 reference

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

31 March 2020

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Identification of CDK4 as a target of c-MYC.

31 March 2020

1 reference

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

31 March 2020

1 reference

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

31 March 2020

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Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes

31 March 2020

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Repression of p15INK4b expression by Myc through association with Miz-1

31 March 2020

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

31 March 2020

1 reference

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

31 March 2020

1 reference

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

31 March 2020

1 reference

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

31 March 2020

1 reference

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

31 March 2020

1 reference

Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation

31 March 2020

1 reference

Cell-cycle progression is not essential for c-Myc to block differentiation

31 March 2020

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The Myc/Max/Mad network and the transcriptional control of cell behavior

31 March 2020

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c-myc regulation during retinoic acid-induced differentiation of F9 cells is posttranscriptional and associated with growth arrest

31 March 2020

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c-myc and c-fos expression in differentiating mouse primary keratinocytes.

31 March 2020

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c-Myc in the Controlm of Cell Proliferation and Embryonic Development

31 March 2020

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Contrasting roles for Myc and Mad proteins in cellular growth and differentiation

31 March 2020

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c-Myc promotes differentiation of human epidermal stem cells

31 March 2020

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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

31 March 2020

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Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

31 March 2020

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An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3

31 March 2020

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Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

31 March 2020

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Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

31 March 2020

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

31 March 2020

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p53 and E2F-1 cooperate to mediate apoptosis

31 March 2020

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

31 March 2020

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E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination

31 March 2020

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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

31 March 2020

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MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

31 March 2020

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

31 March 2020

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Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

31 March 2020

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Breaking the mitochondrial barrier

31 March 2020

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Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

31 March 2020

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c-Myc functionally cooperates with Bax to induce apoptosis

31 March 2020

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

31 March 2020

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Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

31 March 2020

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

31 March 2020

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Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

31 March 2020

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Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

31 March 2020

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A matter of life and death

31 March 2020

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Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

31 March 2020

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

31 March 2020

1 reference

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

1 reference

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

1 reference

Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture

31 March 2020

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

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Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts

31 March 2020

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The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc

31 March 2020

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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

31 March 2020

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BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

31 March 2020

1 reference

Proliferation, cell cycle and apoptosis in cancer

31 March 2020

1 reference

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

1 reference

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

31 March 2020

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

31 March 2020

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Activation of the myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA

31 March 2020

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Angiogenesis is an early event in the generation of myc-induced lymphomas

31 March 2020

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Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells.

31 March 2020

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Different regulation of vascular endothelial growth factor expression by the ERK and p38 kinase pathways in v-ras, v-raf, and v-myc transformed cells

31 March 2020

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A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

31 March 2020

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

31 March 2020

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Recurrent allelic deletions at mouse chromosomes 4 and 14 in Myc-induced liver tumors.

31 March 2020

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

31 March 2020

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c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis

31 March 2020

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Sustained loss of a neoplastic phenotype by brief inactivation of MYC

31 March 2020

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The myc oncogene: MarvelouslY Complex

31 March 2020

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Post-transcriptional deregulation of myc genes in lung cancer cell lines

31 March 2020

1 reference

A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation

31 March 2020

1 reference

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

31 March 2020

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Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

31 March 2020

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Regulation of c-myc expression by PDGF through Rho GTPases.

31 March 2020

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Identification of high-risk breast cancer patients from genetic changes of their tumors

31 March 2020

1 reference

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

31 March 2020

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Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

31 March 2020

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

31 March 2020

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Modelling the molecular circuitry of cancer

31 March 2020

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Creation of human tumour cells with defined genetic elements

31 March 2020

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

31 March 2020

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Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

31 March 2020

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Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

31 March 2020

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Direct activation of TERT transcription by c-MYC.

31 March 2020

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Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen

31 March 2020

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Essential role for oncogenic Ras in tumour maintenance

31 March 2020

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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

31 March 2020

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

31 March 2020

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