hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division (Q28217184)

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Kristi Auer

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Duane A Compton

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Tarun M Kapoor

Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein

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language of work or name

English

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publication date

10 December 2002

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published in

Current Biology

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volume

12

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issue

23

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page(s)

2055-9

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cites work

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TPX2, A novel xenopus MAP involved in spindle pole organization

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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NuMA is required for the organization of microtubules into aster-like mitotic arrays.

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A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.

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Identification of gamma-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans.

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Centrin, centrosomes, and mitotic spindle poles

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The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules

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Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

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Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes.

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Mitotic spindle organization by a plus-end-directed microtubule motor

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Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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Human TPX2 is required for targeting Aurora-A kinase to the spindle

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