Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity (Q28218469)

13

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Oleg N. Demidov

Oleg N Demidov

2

0 references

Anne Kallioniemi

Anne Kallioniemi

11

0 references

Albert J Fornace

Albert J Fornace

12

0 references

Guido Sauter

8

Guido Sauter

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author name string

Dmitry V Bulavin

1

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Shin'ichi Saito

3

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Paivikki Kauraniemi

4

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Crissy Phillips

5

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Sally A Amundson

6

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Concetta Ambrosino

7

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Angel R Nebreda

9

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Carl W Anderson

Post-translational modifications and activation of p53 by genotoxic stresses

10

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language of work or name

English

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publication date

June 2002

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published in

Nature Genetics

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volume

31

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issue

2

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page(s)

210-5

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cites work

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Surfing the p53 network

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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Senescence of human fibroblasts induced by oncogenic Raf.

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p19ARF links the tumour suppressor p53 to Ras

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

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Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

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Molecular cytogenetics of primary breast cancer by CGH

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Tissue microarrays for high-throughput molecular profiling of tumor specimens

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Regulation of p53 function

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Genetic alterations of the p14ARF -hdm2-p53 regulatory pathway in breast carcinoma.

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

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7 January 2021

Compromised HOXA5 function can limit p53 expression in human breast tumours

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7 January 2021

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

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Genetic alterations in breast cancer.

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7 January 2021

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

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7 January 2021

Deregulation of p53/p21Cip1/Waf1 pathway contributes to polyploidy and apoptosis of E1A+cHa-ras transformed cells after gamma-irradiation

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7 January 2021

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.

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Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

1 reference

7 January 2021

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

1 reference

7 January 2021