Patched acts catalytically to suppress the activity of Smoothened (Q28218828)

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M K Cooper

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T Maiti

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P A Beachy

The Hedgehog and Wnt signalling pathways in cancer

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language of work or name

English

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publication date

22 August 2002

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published in

Nature

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volume

418

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issue

6900

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page(s)

892-7

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cites work

1 reference

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

21 April 2017

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Altered neural cell fates and medulloblastoma in mouse patched mutants

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Hedgehog signaling in animal development: paradigms and principles

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Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

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Transmembrane molecular pump activity of Niemann-Pick C1 protein

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Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome

21 April 2017

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 April 2017

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Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

21 April 2017

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The hedgehog pathway and basal cell carcinomas

21 April 2017

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The developmental biology of brain tumors.

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Transducing the hedgehog signal

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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Role of the Drosophila patched gene in positional signalling

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Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

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Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

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7 January 2021

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

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7 January 2021

Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family

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7 January 2021

Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa

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7 January 2021

A freely diffusible form of Sonic hedgehog mediates long-range signalling

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7 January 2021

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00989

7 January 2021

Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

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7 January 2021