Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration (Q28242708)

13

Luigi Naldini

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Daniela Cesana

Daniela Cesana

2

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Eugenio Montini

Eugenio Montini

1

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Alessandro Ambrosi

Alessandro Ambrosi

9

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Claudio Doglioni

Claudio Doglioni

11

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Manfred Schmidt

3

Manfred Schmidt

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Clelia Di Serio

10

Clelia Di Serio

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author name string

Francesca Sanvito

4

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Maurilio Ponzoni

5

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Cynthia Bartholomae

6

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Lucia Sergi Sergi

7

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Fabrizio Benedicenti

HIV-1 integration in the human genome favors active genes and local hotspots

8

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language of work or name

English

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publication date

June 2006

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published in

Nature Biotechnology

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volume

24

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issue

6

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page(s)

687-96

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cites work

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Transcription start regions in the human genome are favored targets for MLV integration

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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

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Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

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Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

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AAV serotype 2 vectors preferentially integrate into active genes in mice

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T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates.

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Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

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Substitution of feline leukemia virus long terminal repeat sequences into murine leukemia virus alters the pattern of insertional activation and identifies new common insertion sites

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Analysis of wild-type and mutant SL3-3 murine leukemia virus insertions in the c-myc promoter during lymphomagenesis reveals target site hot spots, virus-dependent patterns, and frequent error-prone gap repair

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New genes involved in cancer identified by retroviral tagging

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inferred from DOI database lookup

7 January 2021

based on heuristic

Redefining the common insertion site

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Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene

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