The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death (Q28260835)

2

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Toru Hirota

3

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Shin-Ichi Iida

4

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Toshihiro Hara

5

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Shinobu Honda

6

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Naoko Kunitoku

7

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Takashi Sasayama

8

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Yoshimi Arima

9

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Tomotoshi Marumoto

10

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Kageharu Koja

11

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Shin Yonehara

12

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Hideyuki Saya

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

13

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language of work or name

English

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publication date

11 August 2005

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published in

Oncogene

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volume

24

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issue

34

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page(s)

5287-98

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Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

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Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

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Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

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WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis

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A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

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Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

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Apoptosis and the cell cycle

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