The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond (Q28278349)

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29 January 2020

review article

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title

The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond (English)

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29 January 2020

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1

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29 January 2020

Qingjun Wang

series ordinal

2

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29 January 2020

3

Zhenyu Yue

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29 January 2020

language of work or name

English

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publication date

29 March 2010

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29 January 2020

published in

Trends in Cell Biology

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29 January 2020

volume

20

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29 January 2020

issue

6

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29 January 2020

page(s)

355-362

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

29 January 2020

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20 March 2017

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Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11

20 March 2017

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20 March 2017

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Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

20 March 2017

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20 March 2017

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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

20 March 2017

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20 March 2017

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20 March 2017

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

20 March 2017

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Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

20 March 2017

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Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae

20 March 2017

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Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking

20 March 2017

1 reference

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

20 March 2017

1 reference

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

20 March 2017

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A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice

20 March 2017

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20 March 2017

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The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

29 September 2017

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Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

20 March 2017

1 reference

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Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

20 March 2017

1 reference

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

20 March 2017

1 reference

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Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

20 March 2017

1 reference

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Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

20 March 2017

1 reference

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Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae

20 March 2017

1 reference

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

20 March 2017

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Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

20 March 2017

1 reference

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Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway

20 March 2017

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The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells

20 March 2017

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20 March 2017

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7 April 2017

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Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

7 April 2017

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

7 April 2017

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

7 April 2017

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Role for Rab7 in maturation of late autophagic vacuoles

7 April 2017

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The autophagy effector Beclin 1: a novel BH3-only protein

9 May 2017

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29 September 2017

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The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.

29 September 2017

1 reference

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Bif-1/endophilin B1: a candidate for crescent driving force in autophagy

29 September 2017

1 reference

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Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

29 September 2017

1 reference

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Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1

29 September 2017

1 reference

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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

29 September 2017

1 reference

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Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

29 September 2017

1 reference

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Evidence for selective mitochondrial autophagy and failure in aging

29 September 2017

1 reference

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Bcl-2 inhibition of autophagy: a new route to cancer?

29 September 2017

1 reference

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Vacuolar localization of oligomeric alpha-mannosidase requires the cytoplasm to vacuole targeting and autophagy pathway components in Saccharomyces cerevisiae

29 September 2017

1 reference

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RUN domains: a new family of domains involved in Ras-like GTPase signaling

29 September 2017

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Vacuolar import of proteins and organelles from the cytoplasm

29 September 2017

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Phosphatidylinositol-3-OH kinases are Rab5 effectors.

29 September 2017

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Excess peroxisomes are degraded by autophagic machinery in mammals

29 September 2017

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Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.

2 June 2018

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Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes.

27 November 2018

1 reference

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An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins

27 November 2018

1 reference

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Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

27 November 2018

1 reference

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Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

27 November 2018

1 reference

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Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology.

27 November 2018

1 reference

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BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20356743

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TCB.2010.03.002

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20356743%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20356743%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

20356743

2 references