Filopodia: molecular architecture and cellular functions (Q28279460)

Europe PubMed Central

title

Filopodia: molecular architecture and cellular functions (English)

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main subject

filopodium assembly

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Gene Ontology release 2020-05-02

2

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author name string

Pieta K Mattila

series ordinal

1

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language of work or name

English

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publication date

June 2008

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published in

Nature Reviews Molecular Cell Biology

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volume

9

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issue

6

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page(s)

446-54

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cites work

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Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

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Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity

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Mechanism of filopodia initiation by reorganization of a dendritic network

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Filopodia: the fingers that do the walking

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The making of filopodia

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Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction

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Cellular control of actin nucleation

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Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes

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Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells

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Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism

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Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein

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Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer

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Polymerizing actin fibers position integrins primed to probe for adhesion sites

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Initiation of attachment and generation of mature focal adhesions by integrin-containing filopodia in cell spreading

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Three functionally distinct adhesions in filopodia: shaft adhesions control lamellar extension.

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Directed actin polymerization is the driving force for epithelial cell-cell adhesion

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Lamellipodia nucleation by filopodia depends on integrin occupancy and downstream Rac1 signaling

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Signaling and membrane dynamics during phagocytosis: many roads lead to the phagos(R)ome

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Filopodia act as phagocytic tentacles and pull with discrete steps and a load-dependent velocity.

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Micromechanics of filopodia mediated capture of pathogens by macrophages

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A role for myosin VII in dynamic cell adhesion

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Wound healing and inflammation: embryos reveal the way to perfect repair

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Wound healing recapitulates morphogenesis in Drosophila embryos

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Rapid epithelial-sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming

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Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure

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Regulation of growth cone actin filaments by guidance cues

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Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient

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Growth cone steering by a physiological electric field requires dynamic microtubules, microfilaments and Rac-mediated filopodial asymmetry.

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Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation

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Filopodia are required for cortical neurite initiation.

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Ena/VASP Is Required for neuritogenesis in the developing cortex

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Role of actin cytoskeleton in dendritic spine morphogenesis.

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WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac

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Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells

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The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements

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Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

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Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth

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The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics

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Mena is required for neurulation and commissure formation

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Ena/VASP proteins capture actin filament barbed ends

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Ena/VASP proteins have an anti-capping independent function in filopodia formation

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How VASP enhances actin-based motility

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The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation

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Ena/VASP is required for endothelial barrier function in vivo

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Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium

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31 March 2020

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Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42

31 March 2020

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The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.

31 March 2020

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Phylogenetic analysis of the formin homology 2 domain

31 March 2020

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Myosin-X is an unconventional myosin that undergoes intrafilopodial motility.

31 March 2020

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Myosin-X: a molecular motor at the cell's fingertips

31 March 2020

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Myosin X transports Mena/VASP to the tip of filopodia.

31 March 2020

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Myosin-X provides a motor-based link between integrins and the cytoskeleton.

31 March 2020

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A microtubule-binding myosin required for nuclear anchoring and spindle assembly.

31 March 2020

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Myosin X regulates netrin receptors and functions in axonal path-finding

31 March 2020

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Myosin-X is a molecular motor that functions in filopodia formation

31 March 2020

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The motor activity of myosin-X promotes actin fiber convergence at the cell periphery to initiate filopodia formation.

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31 March 2020

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Imaging myosin 10 in cells

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Evidence for fascin cross-links between the actin filaments in coelomocyte filopodia

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Fascins, and their roles in cell structure and function.

31 March 2020

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Role of fascin in filopodial protrusion

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Intrinsic dynamic behavior of fascin in filopodia

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The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation

31 March 2020

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Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature

31 March 2020

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Structural basis for the actin-binding function of missing-in-metastasis

31 March 2020

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Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

31 March 2020

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BAR domains as sensors of membrane curvature: the amphiphysin BAR structure

31 March 2020

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Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.

31 March 2020

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IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness

31 March 2020

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Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex

31 March 2020

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Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases

31 March 2020

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NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling

31 March 2020

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Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain

31 March 2020

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Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties

31 March 2020

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ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension

31 March 2020

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Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains

31 March 2020

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Organization of actin networks in intact filopodia

31 March 2020

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