APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication (Q28272805)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26832400%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication (English)

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6 March 2020

2

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6 March 2020

Ewa Malc

4

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6 March 2020

Piotr A Mieczkowski

5

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6 March 2020

author name string

James I Hoopes

1

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6 March 2020

Tony M Mertz

3

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6 March 2020

Steven A Roberts

6

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6 March 2020

language of work or name

English

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publication date

28 January 2016

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6 March 2020

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6 March 2020

volume

14

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issue

6

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6 March 2020

page(s)

1273-1282

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The APOBEC3 family of retroelement restriction factors

6 March 2020

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Population stratification of a common APOBEC gene deletion polymorphism

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APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons

20 March 2017

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Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

20 March 2017

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

20 March 2017

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

20 March 2017

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20 March 2017

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Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

20 March 2017

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Molecular cloning of an apolipoprotein B messenger RNA editing protein

20 March 2017

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Signatures of mutational processes in human cancer

20 March 2017

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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

7 April 2017

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Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.

7 April 2017

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Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

29 September 2017

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APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions

29 September 2017

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An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

29 September 2017

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Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA

29 September 2017

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DNA replication stress as a hallmark of cancer

29 September 2017

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FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

29 September 2017

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A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage

29 September 2017

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Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.

29 September 2017

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The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.

29 September 2017

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Break-induced replication is a source of mutation clusters underlying kataegis

29 September 2017

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DNA replication and oncogene-induced replicative stress

29 September 2017

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RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

29 September 2017

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Causes and consequences of replication stress

29 September 2017

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29 September 2017

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ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

29 September 2017

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A biochemical analysis linking APOBEC3A to disparate HIV-1 restriction and skin cancer

29 September 2017

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An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

29 September 2017

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29 September 2017

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APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry

29 September 2017

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DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

29 September 2017

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APOBEC3B is an enzymatic source of mutation in breast cancer.

29 September 2017

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A role for the RNA pol II-associated PAF complex in AID-induced immune diversification

29 September 2017

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Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.

29 September 2017

1 reference

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Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

29 September 2017

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dNTP pools determine fork progression and origin usage under replication stress

29 September 2017

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APOBEC3 proteins and genomic stability: the high cost of a good defense

29 September 2017

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Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA

29 September 2017

1 reference

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APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

29 September 2017

1 reference

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Eukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrity

29 September 2017

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Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5

29 September 2017

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Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms

29 September 2017

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Is there any genetic instability in human cancer?

29 September 2017

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Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting

29 September 2017

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Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation

29 September 2017

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Identification of novel deletion polymorphisms in breast cancer.

29 September 2017

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29 September 2017

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

29 September 2017

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APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

29 September 2017

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An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast

29 September 2017

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Effect of reversible inhibition of deoxyribonucleic acid synthesis on the yeast cell cycle

29 September 2017

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Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes.

29 September 2017

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Intrinsic coupling of lagging-strand synthesis to chromatin assembly.

2 June 2018

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Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast

2 June 2018

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RNA polymerase II allows unwinding and rewinding of the DNA and thus maintains a constant length of the transcription bubble.

2 June 2018

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Mutational context and diverse clonal development in early and late bladder cancer.

2 June 2018

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Two levels of protection for the B cell genome during somatic hypermutation.

27 November 2018

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

27 November 2018

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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

27 November 2018

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12 December 2020

The role of the transcription bubble and TFIIB in promoter clearance by RNA polymerase II

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12 December 2020

DNA deaminases AID and APOBEC3G act processively on single-stranded DNA

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12 December 2020

Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis

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Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26832400%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26832400%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

26832400

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26832400%20AND%20SRC:MED&resulttype=core&format=json