Smads and early developmental signaling by the TGFbeta superfamily (Q28280601)

Somatic linker histones cause loss of mesodermal competence in Xenopus

Europe PubMed Central

title

Smads and early developmental signaling by the TGFbeta superfamily (English)

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author name string

M Whitman

series ordinal

1

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language of work or name

English

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publication date

15 August 1998

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published in

Genes & Development

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volume

12

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issue

16

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page(s)

2445-62

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cites work

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A human Mad protein acting as a BMP-regulated transcriptional activator

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Processed Vg1 protein is an axial mesoderm inducer in Xenopus

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Diversity and pattern in the developing spinal cord

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Progressive determination during formation of the anteroposterior axis in Xenopus laevis.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Expression of activin mRNA during early development in Xenopus laevis

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad5 induces ventral fates in Xenopus embryo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Immunodetection of Xenopus bone morphogenetic protein-4 in early embryos.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mads and Smads in TGF beta signalling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

From mouse to frogs: identification and functional analyses of genes required for induction and patterning of the mesoderm

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Betaglycan presents ligand to the TGF beta signaling receptor.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Ca2+ signaling and intracellular Ca2+ binding proteins

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A transcriptional partner for MAD proteins in TGF-beta signalling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Characterization of functional domains within Smad4/DPC4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Conservation of dorsal-ventral patterning in arthropods and chordates.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Nomenclature: vertebrate mediators of TGFbeta family signals

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Morphogens and pattern formation

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Regulation of epidermal induction by BMP2 and BMP7 signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta signal transduction

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad4 and FAST-1 in the assembly of activin-responsive factor

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad6 inhibits signalling by the TGF-beta superfamily

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad proteins physically interact with calmodulin

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Activin signalling and response to a morphogen gradient.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

FGF-4 and BMP-2 have opposite effects on limb growth.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Direct and long-range action of a DPP morphogen gradient.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Regulation of differentiation by TGF-beta

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Bone morphogenetic proteins in the nervous system

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Molecular cloning and functional analysis of a new activin beta subunit: a dorsal mesoderm-inducing activity in Xenopus

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Formation and function of Spemann's organizer

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Localization of MAP Kinase Activity in EarlyXenopusEmbryos: Implications for Endogenous FGF Signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identifiers

DOI

10.1101/GAD.12.16.2445

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

9716398

1 reference

Consolidated OpenCitations Corpus – April 2017