The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter (Q28295923)

1

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J Cui

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N Shao

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E Shyam

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P Reddy

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V N Rao

Double indemnity: p53, BRCA and cancer. p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

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language of work or name

English

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publication date

7 January 1999

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published in

Oncogene

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volume

18

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issue

1

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page(s)

263-8

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cites work

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Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing

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BRCA1 protein products ... Functional motifs...

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Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice

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The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

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Evidence for a transcriptional activation function of BRCA1 C-terminal region

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BRCA1 regulates p53-dependent gene expression

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BRCA1 is a component of the RNA polymerase II holoenzyme

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

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BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases

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Identification of a RING protein that can interact in vivo with the BRCA1 gene product

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BRCA1 physically associates with p53 and stimulates its transcriptional activity.

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Transcriptional activation by BRCA1

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From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

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7 January 2021

Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core

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Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors

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Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

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7 January 2021