Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function (Q28291924)

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Y Litingtung

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E Lee

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K E Young

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J L Corden

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H Westphal

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P A Beachy

Mutations affecting segment number and polarity in Drosophila

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language of work or name

English

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publication date

3 October 1996

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published in

Nature

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volume

383

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issue

6599

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page(s)

407-13

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cites work

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Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

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Sonic hedgehog mediates the polarizing activity of the ZPA

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A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

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Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.

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Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.

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Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos

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Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo

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Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites.

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Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog

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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

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Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.

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A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog

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Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

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Induction of midbrain dopaminergic neurons by Sonic hedgehog

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Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

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Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate

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