ADAMs: key components in EGFR signalling and development (Q28305519)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

ADAMs: key components in EGFR signalling and development (English)

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author name string

Carl P Blobel

series ordinal

1

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language of work or name

English

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publication date

January 2005

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published in

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volume

6

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issue

1

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page(s)

32-43

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cites work

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ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain

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Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

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Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta

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The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion

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Catalytic properties of ADAM19

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The cysteine-rich domain regulates ADAM protease function in vivo

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MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains

21 April 2017

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Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization

21 April 2017

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 April 2017

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Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

21 April 2017

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Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

21 April 2017

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Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

21 April 2017

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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

21 April 2017

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A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

21 April 2017

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Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

21 April 2017

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TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

21 April 2017

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

21 April 2017

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The deaf and the dumb: the biology of ErbB-2 and ErbB-3

21 April 2017

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Roles of Meltrin beta /ADAM19 in the processing of neuregulin

21 April 2017

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Essential roles of Meltrin beta (ADAM19) in heart development

21 April 2017

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Essential role for ADAM19 in cardiovascular morphogenesis

21 April 2017

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 April 2017

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Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

21 April 2017

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Identification of SAP97 as an intracellular binding partner of TACE

21 April 2017

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Evidence for an interaction of the metalloprotease‒disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease‒disintegrin MDC9 with a novel MAD2-related protein, MAD2β

21 April 2017

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Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1

21 April 2017

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The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells

21 April 2017

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Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1

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Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

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Clinical proteomics: Written in blood

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EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

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Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch

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Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

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Membrane-anchored growth factors.

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Membrane protein secretases

31 March 2020

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ADAMs: focus on the protease domain

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Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

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The ADAMs family of metalloproteases: multidomain proteins with multiple functions

31 March 2020

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Shedding light on sheddases: role in growth and development

31 March 2020

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The discovery of receptor tyrosine kinases: targets for cancer therapy

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ADAMs: modulators of cell–cell and cell–matrix interactions

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Metalloproteases: carving out a role in axon guidance

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Implication of APP secretases in notch signaling

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Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence

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The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications

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ADAM family protein Mde10 is essential for development of spore envelopes in the fission yeast Schizosaccharomyces pombe.

31 March 2020

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Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

31 March 2020

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Human ADAM 12 (meltrin alpha) is an active metalloprotease.

31 March 2020

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Catalytic activity of ADAM28

31 March 2020

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Catalytic activity of human ADAM33

31 March 2020

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Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail

31 March 2020

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Regulation of Human ADAM 12 Protease by the Prodomain

31 March 2020

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Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).

31 March 2020

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Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain

31 March 2020

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Structure, function and evolutionary relationship of proteins containing a disintegrin domain

31 March 2020

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Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence

31 March 2020

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Expression of a disintegrin-like protein in cultured human vascular cells and in vivo.

31 March 2020

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Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme

31 March 2020

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Fertilization defects in sperm from mice lacking fertilin beta.

31 March 2020

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Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion

31 March 2020

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Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta

31 March 2020

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Male mice deficient for germ-cell cyritestin are infertile

31 March 2020

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Defining brain wiring patterns and mechanisms through gene trapping in mice.

31 March 2020

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Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

31 March 2020

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Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation

31 March 2020

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Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization

31 March 2020

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TACE is required for the activation of the EGFR by TGF-alpha in tumors

31 March 2020

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Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

31 March 2020

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kuzbanian-mediated cleavage of Drosophila Notch

31 March 2020

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

31 March 2020

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Intramembrane proteolysis by presenilin and presenilin-like proteases

31 March 2020

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

31 March 2020

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Back signaling by the Nrg-1 intracellular domain

31 March 2020

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31 March 2020

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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

31 March 2020

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Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

31 March 2020

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EGFR signal transactivation in cancer cells

31 March 2020

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An essential role for ectodomain shedding in mammalian development

31 March 2020

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Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis

31 March 2020

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Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

31 March 2020

1 reference

TACE is required for fetal murine cardiac development and modeling

31 March 2020

1 reference

Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme

31 March 2020

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Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability

31 March 2020

1 reference

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

31 March 2020

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Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors.

31 March 2020

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The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

31 March 2020

1 reference

Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells

31 March 2020

1 reference

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor

31 March 2020

1 reference

The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation

31 March 2020

1 reference

Epidermal growth factor receptor: mechanisms of activation and signalling.

31 March 2020

1 reference

Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

31 March 2020

1 reference

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

31 March 2020

1 reference

Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis

31 March 2020

1 reference

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors

31 March 2020

1 reference

Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

31 March 2020

1 reference

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

31 March 2020

1 reference

Neuregulins: functions, forms, and signaling strategies

31 March 2020

1 reference

Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme

31 March 2020

1 reference

Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation

31 March 2020

1 reference

Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.

31 March 2020

1 reference

Nuclear localization and possible functions of receptor tyrosine kinases

31 March 2020

1 reference

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

31 March 2020

1 reference

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

31 March 2020

1 reference

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

31 March 2020

1 reference

Potential role for ADAM15 in pathological neovascularization in mice

31 March 2020

1 reference

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

31 March 2020

1 reference

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process

31 March 2020

1 reference

TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation

31 March 2020

1 reference

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

31 March 2020

1 reference

PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13.

31 March 2020

1 reference

PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor

31 March 2020

1 reference

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

31 March 2020

1 reference

Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase

31 March 2020

1 reference

Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

31 March 2020

1 reference

Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).

31 March 2020

1 reference

A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase

31 March 2020

1 reference

Proteomic analysis at the bedside: early detection of cancer

31 March 2020

1 reference

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates

31 March 2020

1 reference

Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.

31 March 2020

1 reference

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

31 March 2020

1 reference

The TNF and TNF receptor superfamilies: integrating mammalian biology

31 March 2020

1 reference