The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation (Q28302850)

Kelch-like family member 12

GOA release 2020-03-11

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Dishevelled segment polarity protein 3a

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1

Stephane Angers

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Randall T. Moon

object named as

Randall T Moon

7

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Michael J MacCoss

6

object named as

Michael J MacCoss

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author name string

Chris J Thorpe

2

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Travis L Biechele

3

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Seth J Goldenberg

4

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Ning Zheng

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

5

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language of work or name

English

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publication date

April 2006

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published in

Nature Cell Biology

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volume

8

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issue

4

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page(s)

348-57

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cites work

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7 January 2021

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

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7 January 2021

Mechanisms of Wnt signaling in development

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7 January 2021

Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction

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7 January 2021

Dishevelled controls cell polarity during Xenopus gastrulation

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7 January 2021

Wnt signaling in lung cancer

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7 January 2021

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7 January 2021

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

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7 January 2021

NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.

1 reference

7 January 2021

Casein kinase 2associates with and phosphorylates Dishevelled

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7 January 2021

Casein kinase Iepsilon modulates the signaling specificities of dishevelled

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7 January 2021

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

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7 January 2021

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

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7 January 2021

A positive role for the PP2A catalytic subunit in Wnt signal transduction.

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7 January 2021

The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos.

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7 January 2021

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

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7 January 2021

The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy

1 reference

7 January 2021

Function and regulation of cullin-RING ubiquitin ligases

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7 January 2021

Protein degradation: CUL-3 and BTB--partners in proteolysis

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7 January 2021

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

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7 January 2021

A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development.

1 reference

7 January 2021

Analysis of Dishevelled signalling pathways during Xenopus development.

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7 January 2021

Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos.

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7 January 2021

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development

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7 January 2021

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.

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7 January 2021

Trimeric G protein-dependent frizzled signaling in Drosophila

1 reference

7 January 2021

Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins

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7 January 2021

The SCF ubiquitin ligase: insights into a molecular machine

1 reference

7 January 2021

A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin

1 reference

7 January 2021

BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

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7 January 2021

BTB proteins as henchmen of Cul3-based ubiquitin ligases

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7 January 2021

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

1 reference

7 January 2021

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

1 reference

7 January 2021

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

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7 January 2021

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

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7 January 2021

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

7 January 2021

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

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7 January 2021

Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase

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7 January 2021

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

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7 January 2021

Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin

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7 January 2021

PR72, a novel regulator of Wnt signaling required for Naked cuticle function

1 reference

7 January 2021

Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

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7 January 2021

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

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7 January 2021

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

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7 January 2021

Protein identification at the low femtomole level from silver-stained gels using a new fritless electrospray interface for liquid chromatography-microspray and nanospray mass spectrometry

1 reference

7 January 2021

Probability-based validation of protein identifications using a modified SEQUEST algorithm

1 reference

7 January 2021

DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics

1 reference

7 January 2021