Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (Q28360110)

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5 November 2019

title

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo (English)

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5 November 2019

11

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5 November 2019

author name string

L J De Windt

1

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5 November 2019

H W Lim

2

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5 November 2019

O F Bueno

3

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5 November 2019

Q Liang

4

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5 November 2019

U Delling

5

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5 November 2019

J C Braz

6

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5 November 2019

B J Glascock

7

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5 November 2019

T F Kimball

8

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5 November 2019

F del Monte

9

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5 November 2019

R J Hajjar

10

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5 November 2019

language of work or name

English

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publication date

1 March 2001

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Proceedings of the National Academy of Sciences of the United States of America

5 November 2019

published in

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volume

98

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issue

6

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5 November 2019

page(s)

3322-3327

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

5 November 2019

cites work

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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling

20 March 2017

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Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

20 March 2017

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Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

20 March 2017

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Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2

20 March 2017

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Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT

20 March 2017

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20 March 2017

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Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

22 April 2017

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Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes

20 March 2017

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

20 March 2017

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Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

20 March 2017

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MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium

20 March 2017

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Cain, a novel physiologic protein inhibitor of calcineurin

20 March 2017

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Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study

20 March 2017

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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

7 April 2017

1 reference

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Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.

29 September 2017

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

29 September 2017

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Signaling pathways for cardiac hypertrophy and failure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=30652

Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases

29 September 2017

1 reference

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Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery

29 September 2017

1 reference

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Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=30652

Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes

29 September 2017

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Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

29 September 2017

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Modulation of ventricular function through gene transfer in vivo

29 September 2017

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The epidemiology of heart failure: the Framingham Study

29 September 2017

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Cardiac-muscle hypertrophy. Differentiation and growth of the heart cell during development

29 September 2017

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Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-kappaB activation

29 September 2017

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Mechanisms of hypertension in cardiac transplantation and the role of cyclosporine

2 June 2018

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Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.031371998

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.031371998

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.031371998

Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy

21 January 2018

1 reference

12 December 2020

Cyclosporin A protects against angiotensin II-induced end-organ damage in double transgenic rats harboring human renin and angiotensinogen genes

1 reference

12 December 2020

Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training

1 reference

12 December 2020

Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats

1 reference

12 December 2020

Cardiac hypertrophy is not a required compensatory response to short-term pressure overload

1 reference

12 December 2020

Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension

1 reference

12 December 2020

Calcineurin inhibitor attenuates left ventricular hypertrophy, leading to prevention of heart failure in hypertensive rats

1 reference

12 December 2020

Calcineurin blockade prevents cardiac mitogen-activated protein kinase activation and hypertrophy in renovascular hypertension

1 reference

12 December 2020

Calcineurin inhibitors and cardiac hypertrophy

1 reference

12 December 2020

Independent inhibition of calcineurin and K+ currents by the immunosuppressant FK-506 in rat ventricle

1 reference

12 December 2020

Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats

1 reference

12 December 2020

Pressure Overload Induces Severe Hypertrophy in Mice Treated With Cyclosporine, an Inhibitor of Calcineurin

1 reference

12 December 2020

Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.031371998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11248077%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

0 references

1 reference

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5 November 2019

PubMed publication ID

11248077

1 reference