Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone (Q28361551)

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scientific article published on June 1, 1988

Language	Label	Description	Also known as
English	Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone	scientific article published on June 1, 1988

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scholarly article

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Inhibition of hepatic fatty acid oxidation at carnitine palmitoyltransferase I by the peroxisome proliferator 2-hydroxy-3-propyl-4-[6-(tetrazol-5-yl) hexyloxy]acetophenone (English)

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1 reference

10.1042/BJ2520409

https://api.crossref.org/works/10.1042/BJ2520409

8 January 2023

1 reference

10.1042/BJ2520409

https://api.crossref.org/works/10.1042/BJ2520409

8 January 2023

author name string

P. S. Foxworthy

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3415664

8 January 2023

P. I. Eacho

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3415664

8 January 2023

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publication date

1 June 1988

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full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3415664/pdf/?tool=EBI

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3415664

8 January 2023

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3415664/?tool=EBI

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3415664

8 January 2023

https://europepmc.org/articles/PMC1149160

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Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3415664

8 January 2023

https://europepmc.org/articles/PMC1149160?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A3415664

8 January 2023

https://portlandpress.com/biochemj/article-pdf/252/2/409/593765/bj2520409.pdf

Portable Document Format

1 reference

10.1042/BJ2520409

https://api.crossref.org/works/10.1042/BJ2520409

8 January 2023

Biochemical Journal

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252

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2

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409-14

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Monoethlenic C20 and C22 fatty acids in marine oil and rapeseed oil. Studies on their oxidation and on their relative ability to inhibit palmitate oxidation in heart and liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

20 March 2017

Metabolism of very long-chain monounsaturated fatty acids (22:1) and the adaptation to their presence in the diet.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

29 September 2017

Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

29 September 2017

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

29 September 2017

Antihyperlipidemic drugs—In vitro effect on the function and structure of rat liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

29 September 2017

Induction of peroxisomal beta-oxidation in rat liver by high-fat diets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Characterization of the stimulatory effect of high-fat diets on peroxisomal beta-oxidation in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

The effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carbonyl-Co-A on mitochondrial oxidations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Physiological role of peroxisomal beta-oxidation in liver of fasted rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its co-enzyme A and carnitine esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Inhibitory effects of some long-chain unsaturated fatty acids on mitochondrial beta-oxidation. Effects of streptozotocin-induced diabetes on mitochondrial beta-oxidation of polyunsaturated fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Effects of DL-2-bromopalmitoyl-CoA and bromoacetyl-CoA in rat liver and heart mitochondria. Inhibition of carnitine palmitoyltransferase and displacement of [14C]malonyl-CoA from mitochondrial binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Interacting effects of L-carnitine and malonyl-CoA on rat liver carnitine palmitoyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Two mechanisms produce tissue-specific inhibition of fatty acid oxidation by oxfenicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Carnitine palmitoyltransferase. Activation by palmitoyl-CoA and inactivation by malonyl-CoA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Characterization of liver enlargement induced by compound LY171883 in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Fatty acid uncoupling of oxidative phosphorylation in rat liver mitochondria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Regulation of palmitate metabolism by carnitine and glucagon in hepatocytes isolated from fasted and carbohydrate refed rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Enhancement of fatty acyl-CoA oxidizing activity in rat liver peroxisomes by di-(i-ethylhexyl)phthalate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Increased Biosynthesis of CoA in the Liver of Rats Treated with Clofibrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

2 June 2018

Variations in tissue contents of coenzyme A thio esters and possible metabolic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149160

27 November 2018

Correlation between the cellular level of long-chain acyl-CoA, peroxisomal beta-oxidation, and palmitoyl-CoA hydrolase activity in rat liver. Are the two enzyme systems regulated by a substrate-induced mechanism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of administration of di-(2-ethylhexyl)phthalate on rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of p-nitroanisole and aniline in isolated hepatocytes of streptozotocin-diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in Peroxisomal Fatty Acid Oxidation in the Diabetic Rat Liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time and dose study on the response of rats to the hypolipidaemic drug fenofibrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of zone-specific hepatic steatosis caused by valproate: inhibition of ketogenesis in periportal regions of the liver lobule

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic peroxisomal changes induced by a tetrazole-substituted alkoxyacetophenone in rats and comparison with other species

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. II. Use of detergents and antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition by valproic acid of the mitochondrial oxidation of monocarboxylic and omega-hydroxymonocarboxylic acids: possible implications for the metabolism of gamma-aminobutyric acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased activity of peroxisomal beta-oxidation in rat liver caused by ethyl 2(5(4-chlorophenyl)pentyl)-oxiran-2-carboxylate: an inhibitor of mitochondrial beta-oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity in the action of hypolipidemic drugs: increase of peroxisomal beta-oxidation largely dissociated from hepatomegaly and peroxisome proliferation in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid-metabolizing enzymes, CoASH and long-chain acyl-CoA in rat liver after treatment with tiadenol, nicotinic acid and niadenate

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a nafenopin-binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic changes in fed rats caused by chronic administration of ethyl 2{5(4-chlorophenyl) pentyl}oxirane-2-carboxylate, a new hypoglycaemic compound

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative studies on di-(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in the rat and hamster

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-chain Acyl-CoA levels in liver from rats fed high-fat diets: is it of significance for an increased peroxisomal beta-oxidation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate, and di(n-octyl) phthalate in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of peroxisomal beta-oxidation in the liver of rats and mice treated with valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of the apparent Ki of carnitine palmitoyltransferase for malonyl-CoA by the diabetic state and reversal by insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of malonyl-CoA and 2-tetradecylglycidyl-CoA with mitochondrial carnitine palmitoyltransferase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/3415664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1042/BJ2520409

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