PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90 (Q28475333)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20865172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90 (English)

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14 February 2020

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1 reference

8

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14 February 2020

7

John R Perfect

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14 February 2020

3

Aimee K Zaas

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14 February 2020

author name string

Shantelle L LaFayette

1

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14 February 2020

Cathy Collins

2

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14 February 2020

Wiley A Schell

4

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14 February 2020

Marisol Betancourt-Quiroz

5

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14 February 2020

A A Leslie Gunatilaka

6

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language of work or name

English

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publication date

26 August 2010

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14 February 2020

volume

6

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issue

8

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14 February 2020

page(s)

e1001069

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Creative Commons Attribution 4.0 International

14 February 2020

copyright license

start time

26 August 2010

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April 2022 Public Data File from Crossref

copyright status

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cites work

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29 September 2017

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A contact-activated kinase signals Candida albicans invasive growth and biofilm development

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29 September 2017

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Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening

29 September 2017

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The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling

29 September 2017

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Mitogen-activated Protein Kinase Stimulation of Ca2+Signaling Is Required for Survival of Endoplasmic Reticulum Stress in Yeast

29 September 2017

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Calcineurin is essential for virulence in Candida albicans

29 September 2017

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Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae

29 September 2017

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Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.

29 September 2017

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Bacteriocins: evolution, ecology, and application

29 September 2017

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Essential role of calcineurin in response to endoplasmic reticulum stress

29 September 2017

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The direct cost and incidence of systemic fungal infections

29 September 2017

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Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4.

29 September 2017

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Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997.

29 September 2017

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Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin

29 September 2017

1 reference

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Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

29 September 2017

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The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2928802

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

29 September 2017

1 reference

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Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesis

29 September 2017

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The Candida albicans PKC1 gene encodes a protein kinase C homolog necessary for cellular integrity but not dimorphism

29 September 2017

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Monophyletic origins of the metazoa: an evolutionary link with fungi

29 September 2017

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Synthesis and evaluation of neoplastic cell growth inhibition of 1-N-alkylamide analogues of glycero-3-phosphocholine

29 September 2017

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Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence

29 September 2017

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Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling

2 June 2018

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A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function

2 June 2018

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The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans.

2 June 2018

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Chelerythrine is a potent and specific inhibitor of protein kinase C.

2 June 2018

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A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle

2 June 2018

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Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1

2 June 2018

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The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis.

2 June 2018

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The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans.

21 January 2018

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Metabolic control of antifungal drug resistance.

21 January 2018

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CRZ1, a target of the calcineurin pathway in Candida albicans

21 January 2018

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Calcineurin is required for Candida albicans to survive calcium stress in serum

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1001069

Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

21 January 2018

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Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1001069

Targeting the protein kinase C family: are we there yet?

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1001069

Isolation and partial characterization of Hsp90 from Candida albicans

21 January 2018

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12 December 2020

Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient

1 reference

12 December 2020

Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway

1 reference

12 December 2020

Isolation and Partial Characterization of Four Host-specific Toxins of Helminthosporium maydis (Race T)

1 reference

12 December 2020

10.1371/JOURNAL.PPAT.1001069

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20865172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20865172%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

20865172

2 references