Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice (Q28476761)

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English	Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice	scientific article

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12 February 2020

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909419%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

amyotrophic lateral sclerosis

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inferred from title

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Dominic J Wells

4

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12 February 2020

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Hannah M Kaneb

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12 February 2020

Paul S Sharp

2

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12 February 2020

Nazanin Rahmani-Kondori

3

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12 February 2020

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1 September 2011

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12 February 2020

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12 February 2020

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12 February 2020

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12 February 2020

e24189

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12 February 2020

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Creative Commons Attribution 4.0 International

1 September 2011

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April 2022 Public Data File from Crossref

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No benefit from chronic lithium dosing in a sibling-matched, gender balanced, investigator-blinded trial using a standard mouse model of familial ALS

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Design, power, and interpretation of studies in the standard murine model of ALS

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19 March 2017

Role of AMP-activated protein kinase in mechanism of metformin action

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications.

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29 September 2017

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis.

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29 September 2017

Evidence-based drug treatment in amyotrophic lateral sclerosis and upcoming clinical trials

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29 September 2017

New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser

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29 September 2017

The "dying-back" phenomenon of motor neurons in ALS.

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29 September 2017

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

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29 September 2017

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

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29 September 2017

Inflammation in ALS and SMA: sorting out the good from the evil

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29 September 2017

Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway

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29 September 2017

Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis

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29 September 2017

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

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29 September 2017

Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications

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29 September 2017

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials.

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29 September 2017

Neuroprotective agents for clinical trials in ALS: a systematic assessment

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29 September 2017

Experimental therapeutics in transgenic mouse models of Huntington's disease

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29 September 2017

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

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29 September 2017

Metformin reverses fatty liver disease in obese, leptin-deficient mice

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29 September 2017

Analysis of serial measurements in medical research

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Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin

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21 January 2018

Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.

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21 January 2018

Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells

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21 January 2018

Metformin therapy in a transgenic mouse model of Huntington's disease.

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21 January 2018

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression.

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21 January 2018

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

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21 January 2018

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

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21 January 2018

The effect of peripheral nerve injury on disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

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21 January 2018

Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice.

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21 January 2018

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

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21 January 2018

Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS.

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21 January 2018

Metformin has direct effects on human ovarian steroidogenesis

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21 January 2018

ALS disease onset may occur later in patients with pre-morbid diabetes mellitus

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21 January 2018

Metformin attenuates blood lipid peroxidation and potentiates antioxidant defense in high fructose-fed rats

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Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis

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27 November 2018

Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21909419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21909419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21909419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/21909419

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0024189

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909419%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2011PLoSO...624189K

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21909419%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

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12 February 2020

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