Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect (Q28477166)

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English	Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect	scientific article

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Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect (English)

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author name string

Minsuh Seo

1

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Jeong-Do Kim

2

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David Neau

3

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Inder Sehgal

4

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Yong-Hwan Lee

5

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language of work or name

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publication date

2011

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6

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9

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e24179

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copyright license

Creative Commons Attribution 4.0 International

21 September 2011

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April 2022 Public Data File from Crossref

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1 reference

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19 March 2017

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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Cancer cell metabolism: Warburg and beyond

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19 March 2017

A direct substrate-substrate interaction found in the kinase domain of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

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Glycolysis inhibition for anticancer treatment

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Mitochondrial tumour suppressors: a genetic and biochemical update

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19 March 2017

Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy

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19 March 2017

The CCP4 suite: programs for protein crystallography

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19 March 2017

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

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19 March 2017

On the Origin of Cancer Cells

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29 September 2017

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

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19 March 2017

Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine

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19 March 2017

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

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19 March 2017

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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19 March 2017

Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure

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19 March 2017

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme

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19 March 2017

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6 April 2017

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

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19 March 2017

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

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Targeting metabolic transformation for cancer therapy.

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29 September 2017

Tumor suppressors and cell metabolism: a recipe for cancer growth

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29 September 2017

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

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29 September 2017

Hypoxia signalling in cancer and approaches to enforce tumour regression

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29 September 2017

Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

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29 September 2017

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

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29 September 2017

Managing molecular diversity

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29 September 2017

Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.

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29 September 2017

High-throughput crystallography for lead discovery in drug design.

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29 September 2017

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: suiting structure to need, in a family of tissue-specific enzymes.

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29 September 2017

Somatic mutations of the mitochondrial genome in human colorectal tumours

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Control of apoptosis by the cellular ATP level

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29 September 2017

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29 September 2017

Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors

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29 September 2017

Structure-based strategies for drug design and discovery

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29 September 2017

6 Statistical analysis of enzyme kinetic data

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29 September 2017

PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells

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21 January 2018

Knowledge-based scoring function to predict protein-ligand interactions.

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21 January 2018

Energy deregulation: licensing tumors to grow

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Biochemical determinants of apoptosis and necrosis

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based on heuristic

inferred from PubMed ID database lookup

Fructose 2,6-bisphosphate metabolism in Ehrlich ascites tumour cells

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https://pubmed.ncbi.nlm.nih.gov/21957443

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based on heuristic

inferred from PubMed ID database lookup

A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate

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Identifiers

10.1371/JOURNAL.PONE.0024179

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2011PLoSO...624179S

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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