Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors (Q28484546)

4

0 references

Julen Oyarzabal

Julen Oyarzabal

12

0 references

Joaquín Pastor

1 reference

ORCID Public Data File 2021

Gustavo Saluste

1

Gustavo Saluste

0 references

Guido Kurz

7

Guido Kurz

0 references

Paolo Pevarello

9

Paolo Pevarello

0 references

Antonio Salgado

8

Antonio Salgado

0 references

author name string

Maria I Albarran

2

0 references

Rosa M Alvarez

3

0 references

Miguel Angel Ortega

5

0 references

Carmen Blanco

6

0 references

James R Bischoff

10

0 references

Joaquin Pastor

Creative Commons Attribution 4.0 International

11

0 references

language of work or name

English

0 references

publication date

2012

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published in

PLOS One

0 references

volume

7

0 references

issue

10

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page(s)

e45964

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copyright license

start time

24 October 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

19 March 2017

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Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

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Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase

19 March 2017

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

19 March 2017

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

19 March 2017

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Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

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The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

19 March 2017

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Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

19 March 2017

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Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

29 September 2017

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PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

29 September 2017

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Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

29 September 2017

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Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

29 September 2017

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

29 September 2017

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Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

29 September 2017

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Selection of molecules based on shape and electrostatic similarity: proof of concept of "electroforms".

29 September 2017

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Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

29 September 2017

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Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.

29 September 2017

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The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway

29 September 2017

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Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer

29 September 2017

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Transcriptional regulation of Pim-1 kinase in vascular smooth muscle cells and its role for proliferation

2 June 2018

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Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists.

2 June 2018

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Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region

2 June 2018

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The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases

2 June 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Assessing the performance of OMEGA with respect to retrieving bioactive conformations

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23115625

inferred from PubMed ID database lookup

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based on heuristic

Molecular shape and electrostatics in the encoding of relevant chemical information

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23115625