The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target (Q28485125)

24 January 2017

title

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target (English)

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24 January 2017

main subject

Neisseria gonorrhoeae

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author name string

Ryszard A. Zielke

1

1 reference

24 January 2017

Igor H. Wierzbicki

2

1 reference

24 January 2017

Benjamin I. Baarda

3

1 reference

24 January 2017

Aleksandra E. Sikora

4

1 reference

24 January 2017

publication date

30 June 2015

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24 January 2017

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24 January 2017

volume

15

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24 January 2017

page(s)

129

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Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future

24 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The universally conserved prokaryotic GTPases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Structural and biochemical analysis of the Obg GTP binding protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Quantitative proteomics of the Neisseria gonorrhoeae cell envelope and membrane vesicles for the discovery of potential therapeutic targets

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Analysis and expansion of the role of the Escherichia coli protein ProQ.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Current and future treatment options for gonorrhoea

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Bacterial Obg proteins: GTPases at the nexus of protein and DNA synthesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Escherichia coli peripheral inner membrane proteome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Genetic Manipulation of Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Composition and Metabolic Phenotype of Neisseria gonorrhoeae Biofilms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Structure-function relationships of the G domain, a canonical switch motif

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Assembling the archaeal ribosome: roles for translation-factor-related GTPases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Chlamydia abortus YhbZ, a truncated Obg family GTPase, associates with the Escherichia coli large ribosomal subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Bacterial membrane proteomics.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Identification and characterization of gonococcal iron transport systems as potential vaccine antigens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Functional analysis of the essential GTP-binding-protein-coding gene cgtA of Vibrio cholerae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Antibiotics and the ribosome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Vibrio harveyi GTPase CgtAV is essential and is associated with the 50S ribosomal subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Gonococcal infections in neonates and young children

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Escherichia coli GTPase CgtAE cofractionates with the 50S ribosomal subunit and interacts with SpoT, a ppGpp synthetase/hydrolase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Caulobacter crescentus CgtAC protein cosediments with the free 50S ribosomal subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Overexpression of two different GTPases rescues a null mutation in a heat-induced rRNA methyltransferase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Roles of the recJ and recN genes in homologous recombination and DNA repair pathways of Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The N-terminal domain of the Caulobacter crescentus CgtA protein does not function as a guanine nucleotide exchange factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Expression of AniA, the major anaerobically induced outer membrane protein of Neisseria gonorrhoeae, provides protection against killing by normal human sera

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Caulobacter crescentus CgtA protein displays unusual guanine nucleotide binding and exchange properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Identification of an essential Caulobacter crescentus gene encoding a member of the Obg family of GTP-binding proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Biochemical characterization of the essential GTP-binding protein Obg of Bacillus subtilis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Genetic Transformation of Neisseria gonorrhoeae to Streptomycin Resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Manipulation of intracellular magnesium content in polymyxin B nonapeptide-sensitized Escherichia coli by ionophore A23187.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Isolation and nucleotide sequence of the gene (aniA) encoding the major anaerobically induced outer membrane protein of Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Autolysis of Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Degradation of the polysaccharide component of gonococcal lipopolysaccharide by gonococcal and meningococcal sonic extracts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Autolysis of Neisseria gonorrhoeae. Relation between mechanical stability and viability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Mechanism of autolysis of Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Autolysis of Neisseria gonorrhoeae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

A Case of Angina Pectoris with Terminal Uraemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

G-protein control of the ribosome-associated stress response protein SpoT.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Investigation of the GTP-binding/GTPase cycle of Cdc42Hs using extrinsic reporter group fluorescence

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Fluorescent guanine nucleotide analogs and G protein activation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Recombination among protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the protein II family

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

2 June 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Crystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Biochemical properties of the Vibrio harveyi CgtAV GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

A genome-based approach for the identification of essential bacterial genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

The GTP binding protein Obg homolog ObgE is involved in ribosome maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

The Caulobacter crescentus GTPase CgtAC is required for progression through the cell cycle and for maintaining 50S ribosomal subunit levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Defect in the formation of 70S ribosomes caused by lack of ribosomal protein L34 can be suppressed by magnesium

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Alanine scan mutagenesis of the switch I domain of the Caulobacter crescentus CgtA protein reveals critical amino acids required for in vivo function

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Ceftriaxone-resistant Neisseria gonorrhoeae, Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12866-015-0453-1

Laboratory maintenance of Neisseria gonorrhoeae

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

Threat to cefixime treatment for gonorrhea

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4487204

High magnesium content of Escherichia coli B

27 November 2018

1 reference

12 December 2020

Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010

1 reference

12 December 2020

Obg/CtgA, a signaling protein that controls replication, translation, and morphological development?

1 reference

12 December 2020

Deficiency of essential GTP-binding protein ObgE in Escherichia coli inhibits chromosome partition

1 reference

12 December 2020

Factors affecting autolysis of Neisseria gonorrhoeae

1 reference

12 December 2020

Pilus expression in Neisseria gonorrhoeae involves chromosomal rearrangement

1 reference

12 December 2020

An essential GTP-binding protein functions as a regulator for differentiation in Streptomyces coelicolor

1 reference

12 December 2020

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1 reference

12 December 2020

10.1186/S12866-015-0453-1

Identifiers

DOI

0 references

Dimensions Publication ID

1039465704

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PMC publication ID

4487204

0 references

1 reference