Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable (Q28482395)

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English	Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 June 2017

Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable (English)

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Europe PubMed Central

PubMed publication ID

21 June 2017

Andrew J. Wilson

4

object named as

Andrew J Wilson

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Thomas A Edwards

3

object named as

Thomas A Edwards

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Jonathan C Fuller

object named as

Jonathan C Fuller

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Michael R. Shirts

5

object named as

Michael R Shirts

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Europe PubMed Central

PubMed publication ID

21 June 2017

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Richard M Jackson

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Europe PubMed Central

PubMed publication ID

21 June 2017

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publication date

20 August 2012

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Europe PubMed Central

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21 June 2017

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http://eprints.whiterose.ac.uk/84357/

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White Rose Research Online

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https://doi.org/10.1371/journal.pone.0043253

copyright license

Creative Commons Attribution

object of statement has role

published version

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1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

7

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Europe PubMed Central

PubMed publication ID

21 June 2017

8

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Europe PubMed Central

PubMed publication ID

21 June 2017

e43253

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Europe PubMed Central

PubMed publication ID

21 June 2017

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Creative Commons Attribution 4.0 International

20 August 2012

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April 2022 Public Data File from Crossref

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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7 April 2017

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7 April 2017

Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.

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29 September 2017

Helix-mediated protein--protein interactions as targets for intervention using foldamers

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29 September 2017

Small-molecule inhibitors of MDM2 as new anticancer therapeutics

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Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

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29 September 2017

Beta-peptides with improved affinity for hDM2 and hDMX.

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29 September 2017

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

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29 September 2017

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

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Exploring the helix-coil transition via all-atom equilibrium ensemble simulations

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Molecular characterization of the hdm2-p53 interaction

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29 September 2017

Identification of novel mdm2 binding peptides by phage display.

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29 September 2017

High Specificity in Protein Recognition by Hydrogen‐Bond‐Surrogate α‐Helices: Selective Inhibition of the p53/MDM2 Complex

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2 June 2018

Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction

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Configurational preferences of arylamide α-helix mimetics via alchemical free energy calculations of relative binding affinities.

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N-alkylated oligoamide alpha-helical proteomimetics

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Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition.

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Study of MDM2 binding to p53-analogues: affinity, helicity, and applicability to drug design

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Ab initio calculations of intramolecular parameters for a class of arylamide polymers

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NMR structure of a complex between MDM2 and a small molecule inhibitor

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https://pubmed.ncbi.nlm.nih.gov/22916232

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(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22916232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0043253

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Europe PubMed Central

PubMed publication ID

21 June 2017

2012PLoSO...743253F

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10.1371/JOURNAL.PONE.0043253

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Consolidated OpenCitations Corpus – April 2017

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PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

ResearchGate publication ID

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2-s2.0-84865168161

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