The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C (Q28587901)

31 January 2017

title

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C (English)

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Mechanistic target of rapamycin kinase

31 January 2017

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RPTOR independent companion of MTOR, complex 2

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Thymoma viral proto-oncogene 1

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Heat shock protein 90, alpha (cytosolic), class A member 1

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15

Estela Jacinto

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31 January 2017

8

Alexandra C. Newton

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31 January 2017

11

William C. Sessa

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31 January 2017

Valeria Facchinetti

1

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31 January 2017

Weiming Ouyang

2

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31 January 2017

Hua Wei

3

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31 January 2017

Nelyn Soto

4

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31 January 2017

Adam Lazorchak

5

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31 January 2017

Christine Gould

6

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31 January 2017

Carolyn Lowry

7

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31 January 2017

Yuxin Mao

9

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31 January 2017

Robert Q. Miao

10

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31 January 2017

Jun Qin

12

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31 January 2017

Pumin Zhang

13

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31 January 2017

Bing Su

14

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31 January 2017

language of work or name

English

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publication date

23 July 2008

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31 January 2017

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31 January 2017

volume

27

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31 January 2017

issue

14

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31 January 2017

page(s)

1932–1943

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Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation

31 January 2017

cites work

1 reference

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

17 March 2017

1 reference

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

17 March 2017

1 reference

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

17 March 2017

1 reference

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

17 March 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

17 March 2017

1 reference

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TOR signaling in growth and metabolism

17 March 2017

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

17 March 2017

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Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization

17 March 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

17 March 2017

1 reference

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

17 March 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

17 March 2017

1 reference

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

17 March 2017

1 reference

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

17 March 2017

1 reference

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Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site

17 March 2017

1 reference

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Molecular chaperones in the cytosol: from nascent chain to folded protein

17 March 2017

1 reference

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Hierarchical phosphorylation of the translation inhibitor 4E-BP1

17 March 2017

1 reference

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Modulation of Akt kinase activity by binding to Hsp90

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

17 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

17 March 2017

1 reference

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Dual requirement for a newly identified phosphorylation site in p70s6k

17 March 2017

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

17 March 2017

1 reference

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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

17 March 2017

1 reference

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

17 March 2017

1 reference

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TOR regulation of AGC kinases in yeast and mammals

7 April 2017

1 reference

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The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

29 September 2017

1 reference

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Molecular chaperones and protein kinase quality control.

29 September 2017

1 reference

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Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

29 September 2017

1 reference

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mTOR, translation initiation and cancer

29 September 2017

1 reference

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Regulation of ribosome biogenesis: where is TOR?

29 September 2017

1 reference

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Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif

29 September 2017

1 reference

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Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

29 September 2017

1 reference

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Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases

29 September 2017

1 reference

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

29 September 2017

1 reference

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The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.

29 September 2017

1 reference

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Mammalian TOR: a homeostatic ATP sensor

29 September 2017

1 reference

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Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

Akt activation by growth factors is a multiple-step process: the role of the PH domain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2486276

Regulation of translation initiation by FRAP/mTOR

27 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2008.120

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2008.120

1 reference

1 reference

1 reference

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