The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease (Q28594242)

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English	The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease	scientific journal article

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scholarly article

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PubMed publication ID

31 January 2017

The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease (English)

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PubMed publication ID

31 January 2017

neuroendocrinology

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based on heuristic

inferred from title

Secretogranin V

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GOA release 2020-03-11

Cushing's disease

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inferred from title

author name string

C. H. Westphal

1

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31 January 2017

L. Muller

2

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31 January 2017

A. Zhou

3

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31 January 2017

X. Zhu

4

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31 January 2017

S. Bonner-Weir

5

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31 January 2017

M. Schambelan

6

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31 January 2017

D. F. Steiner

7

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31 January 2017

I. Lindberg

8

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31 January 2017

P. Leder

9

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PubMed publication ID

31 January 2017

language of work or name

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publication date

5 March 1999

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PubMed publication ID

31 January 2017

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PubMed publication ID

31 January 2017

96

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PubMed publication ID

31 January 2017

5

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31 January 2017

689–700

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PubMed publication ID

31 January 2017

Hormonal regulation of POMC gene expression

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PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

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7B2 is a specific intracellular binding protein of the prohormone convertase PC2

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7 January 2021

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Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex

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7 January 2021

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Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

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7 January 2021

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Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA.

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Pituitary hyperplasia induced by ectopic expression of nerve growth factor

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Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter

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7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

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Structural organization of the gene encoding the neuroendocrine chaperone 7B2

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Transmembrane signals mediating adrenocorticotropin release from mouse anterior pituitary cells

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Histological evaluation of the dopaminergic regulation of proopiomelanocortin gene expression in the intermediate lobe of the rat pituitary, involving in situ hybridization and [3H]thymidine uptake measurement

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Differentiation in paediatric peripheral primitive neuroectodermal tumours of bone. A critical contribution to its assessment.

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

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Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

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Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.

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Tissue distribution and molecular forms of a novel pituitary protein in the rat.

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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Processing site blockade results in more efficient conversion of proenkephalin to active opioid peptides

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Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates

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Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment

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Pan-neuronal mRNA expression of the secretory polypeptide 7B2

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Clinical and biochemical evaluation of Cushing's syndrome

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Secretory protein 7B2. A novel tumor marker of medullary carcinoma of the thyroid

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1 reference

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The proprotein convertases

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1 reference

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Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC2.

1 reference

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7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity

1 reference

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1 reference

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Identifiers

10.1016/S0092-8674(00)80579-6

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PubMed publication ID

1 reference

PubMed publication ID

31 January 2017

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