Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis (Q28591514)

31 January 2017

title

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis (English)

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experimental autoimmune encephalomyelitis

31 January 2017

main subject

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Myeloid differentiation primary response gene 88

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GOA release 2020-03-11

Toll-like receptor 4

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GOA release 2020-03-11

Toll-like receptor 9

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GOA release 2020-03-11

4

Olle Kämpe

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31 January 2017

Monica Marta

1

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author name string

Asa Andersson

series ordinal

2

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31 January 2017

Magnus Isaksson

series ordinal

3

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31 January 2017

Anna Lobell

series ordinal

5

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31 January 2017

language of work or name

English

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publication date

1 February 2008

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European Journal of Immunology

31 January 2017

published in

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31 January 2017

volume

38

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31 January 2017

issue

2

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31 January 2017

page(s)

565–575

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

31 January 2017

cites work

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Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response

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Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy.

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TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG

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TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease

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Toll-like receptors control activation of adaptive immune responses

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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7 January 2021

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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7 January 2021

Transforming growth factor-beta induces development of the T(H)17 lineage

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7 January 2021

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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7 January 2021

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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7 January 2021

A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

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7 January 2021

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

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Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity

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7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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7 January 2021

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

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Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells

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7 January 2021

Nasal administration of multiple antigens suppresses experimental autoimmune myasthenia gravis, encephalomyelitis and neuritis

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7 January 2021

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

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7 January 2021

Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism

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7 January 2021

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

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7 January 2021

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7 January 2021

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

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7 January 2021

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

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7 January 2021

Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFNbeta

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7 January 2021

CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo

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7 January 2021

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

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7 January 2021

T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis

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7 January 2021

B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide

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7 January 2021

The role of CD8(+) T cells in multiple sclerosis and its animal models

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7 January 2021

Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

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7 January 2021

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

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7 January 2021

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

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7 January 2021

Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator

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7 January 2021

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7 January 2021

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7 January 2021

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction

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7 January 2021

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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7 January 2021