Spatial segregation of gamma-secretase and substrates in distinct membrane domains (Q28591973)

4 July 2017

title

Spatial segregation of gamma-secretase and substrates in distinct membrane domains (English)

1 reference

4 July 2017

1 reference

Nicastrin

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Syntaxin 6

1 reference

Presenilin 1

1 reference

Jagged 2

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Beta-site APP cleaving enzyme 1

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Flotillin 2

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Amyloid beta (A4) precursor protein

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author name string

Haipeng Cheng

2

1 reference

4 July 2017

Seong-Hun Kim

3

1 reference

4 July 2017

Ying Chen

4

1 reference

4 July 2017

Gopal Thinakaran

8

1 reference

4 July 2017

Kulandaivelu S Vetrivel

1

1 reference

4 July 2017

Natalie Y Barnes

5

1 reference

4 July 2017

Angèle T Parent

6

1 reference

4 July 2017

Sangram S Sisodia

7

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4 July 2017

language of work or name

English

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publication date

10 May 2005

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4 July 2017

number of pages

9

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Journal of Biological Chemistry

inferred from page(s)

published in

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4 July 2017

volume

280

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4 July 2017

issue

27

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4 July 2017

page(s)

25892-25900

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

4 July 2017

cites work

1 reference

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17 March 2017

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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

17 March 2017

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Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

17 March 2017

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

17 March 2017

1 reference

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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

17 March 2017

1 reference

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Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

17 March 2017

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17 March 2017

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

17 March 2017

1 reference

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

17 March 2017

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Calcium depletion dissociates and activates heterodimeric notch receptors

17 March 2017

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

17 March 2017

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Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons

17 March 2017

1 reference

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

17 March 2017

1 reference

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

17 March 2017

1 reference

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

17 March 2017

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Presenilin attenuates receptor-mediated signaling and synaptic function.

7 April 2017

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29 September 2017

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The gamma-secretase complex: machinery for intramembrane proteolysis

29 September 2017

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BACE1: the beta-secretase enzyme in Alzheimer's disease

29 September 2017

1 reference

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Dual mechanisms for shedding of the cellular prion protein

29 September 2017

1 reference

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

29 September 2017

1 reference

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Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

29 September 2017

1 reference

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The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

29 September 2017

1 reference

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

29 September 2017

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

29 September 2017

1 reference

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New frontiers in Alzheimer's disease genetics

29 September 2017

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Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

29 September 2017

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Roles of lipid rafts in membrane transport

29 September 2017

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Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

29 September 2017

1 reference

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Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

29 September 2017

1 reference

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The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties.

29 September 2017

1 reference

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

29 September 2017

1 reference

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Neuronal membrane cholesterol loss enhances amyloid peptide generation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

3 June 2018

1 reference

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Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein

3 June 2018

1 reference

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Stable association of presenilin derivatives and absence of presenilin interactions with APP.

3 June 2018

1 reference

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Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

3 June 2018

1 reference

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Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Gamma-secretase activity is present in rafts but is not cholesterol-dependent

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1201532

Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor

27 November 2018

1 reference

12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 December 2020

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M503570200

1 reference

OpenCitations bibliographic resource ID

4 July 2017

1503046

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

4 July 2017

1 reference