Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing (Q28610145)

3 February 2017

title

Enzyme hyperspecificity. Rejection of threonine by the valyl-tRNA synthetase by misacylation and hydrolytic editing (English)

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transfer RNA aminoacylation

3 February 2017

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ChEBI release 2020-05-28

ChEBI ID

64851

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A182209

reference URL

25 December 2022

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25 December 2022

author name string

A. R. Fersht

1

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3 February 2017

M. M. Kaethner

2

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3 February 2017

language of work or name

English

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publication date

27 July 1976

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full work available at URL

3 February 2017

https://pubs.acs.org/doi/pdf/10.1021/bi00660a026

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25 December 2022

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3 February 2017

volume

15

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3 February 2017

issue

15

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3 February 2017

page(s)

3342–3346

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Studies on the mechanism of deacylation of aminoacyl-tRNAs by aminoacyl-tRNA synthetases in the absence of adenosine monophosphate and pyrophosphate.

3 February 2017

cites work

4

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Correction of aminoacylation errors: evidence for a non significant role of the aminoacyl-tRNA synthetase catalysed deacylation of aminoacyl-tRNAs.

25 December 2022

5

1 reference

Demonstration of two active sites on a monomeric aminoacyl-tRNA synthetase. Possible roles of negative cooperativity and half-of-the-sites reactivity in oligomeric enzymes

25 December 2022

8

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Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases

25 December 2022

9

1 reference

Demonstration of two reaction pathways for the aminoacylation of tRNA. Application of the pulsed quenched flow technique

25 December 2022

10

1 reference

Mechanism of aminoacylation of tRNA. Proof of the aminoacyl adenylate pathway for the isoleucyl- and tyrosyl-tRNA synthetases from Escherichia coli K12

25 December 2022

11

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Ultracentrifuge Studies on Binding of Aliphatic Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia coli MRE 600

25 December 2022

12

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Separation of transfer ribonucleic acid by sepharose chromatography using reverse salt gradients

25 December 2022

14

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THE FREQUENCY OF ERRORS IN PROTEIN BIOSYNTHESIS

25 December 2022

15

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The frequency of errors in protein biosynthesis

25 December 2022

16

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MECHANISM OF AMINOACYL RNA SYNTHESIS: STUDIES WITH ISOLATED AMINOACYL ADENYLATE COMPLEXES OF ISOLEUCYL RNA SYNTHETASE

25 December 2022

17

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Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate

25 December 2022

19

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Enzymatic Deacylation of Methionyl-tRNAfMef Catalysed by Methionyl, Isoleucyl and Phenylalanyl-tRNA Synthetases

25 December 2022

20

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Isoleucyl‐tRNA synthetase from baker's yeast: The 3′‐hydroxyl group of the 3′‐terminal ribose is essential for preventing misacylation of tRNAIle‐C‐C‐A with misactivated valine

25 December 2022

21

1 reference

Studies on valyl-tRNA synthetase and tRNA from Escherichia coli. I. Purification and properties of the enzyme from normal Escherichia coli strains

25 December 2022

22

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Phenylalanyl-tRNA Synthetase and Isoleucyl-tRNA Phe : A Possible Verification Mechanism for Aminoacyl-tRNA

25 December 2022

23

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Recognition of tRNA by isoleucyl-tRNA synthetase. Effect of substrates on the dynamics of tRNA-enzyme interaction

25 December 2022

24

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On the properties and utility of a membrane filter assay in the study of isoleucyl-tRNA synthetase

25 December 2022

25

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25 December 2022

Identifiers

DOI

10.1021/BI00660A026

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