Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system (Q28750271)

Cold Spring Harbor Perspectives in Biology

Europe PubMed Central

title

Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system (English)

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Rolf Zeller

2

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author name string

Jean-Denis Bénazet

series ordinal

1

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language of work or name

English

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publication date

October 2009

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published in

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volume

1

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issue

4

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page(s)

a001339

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cites work

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Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb

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16 March 2017

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Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

16 March 2017

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Some distal limb structures develop in mice lacking Sonic hedgehog signaling

16 March 2017

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Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

16 March 2017

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Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

16 March 2017

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Fgf10 is essential for limb and lung formation

16 March 2017

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Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

16 March 2017

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The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

16 March 2017

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FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

16 March 2017

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Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limb

16 March 2017

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Sonic hedgehog mediates the polarizing activity of the ZPA

16 March 2017

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Positional information and the spatial pattern of cellular differentiation

7 April 2017

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7 April 2017

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Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

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A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning

9 May 2017

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An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

3 June 2018

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Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity

3 June 2018

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Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

3 June 2018

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Regulation of Gremlin expression in the posterior limb bud.

3 June 2018

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Cholesterol modification restricts the spread of Shh gradient in the limb bud.

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

It takes time to make a pinky: unexpected insights into how SHH patterns vertebrate digits

3 June 2018

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Novel lipid modifications of secreted protein signals

3 June 2018

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Pattern formation: old models out on a limb.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

A freely diffusible form of Sonic hedgehog mediates long-range signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Fgf8 is required for outgrowth and patterning of the limbs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Gli genes and limb development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Dorso-ventral limb polarity and origin of the ridge: on the fringe of independence?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

A positive feedback loop coordinates growth and patterning in the vertebrate limb.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Local application of retinoic acid to the limb bond mimics the action of the polarizing region

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Positional Information in Chick Limb Morphogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

The spatial and temporal distribution of polarizing activity in the flank of the pre-limb-bud stages in the chick embryo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Pattern regulation in epimorphic fields

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Integration of growth and specification in chick wing digit-patterning.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Fgf signaling controls the number of phalanges and tip formation in developing digits.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Fgf8 signalling from the AER is essential for normal limb development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Developmental biology. Giving limbs a hand.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2773624

Positional signalling and specification of digits in chick limb morphogenesis

27 November 2018

1 reference

12 December 2020

The number of polarizing region cells required to specify additional digits in the developing chick wing

1 reference

12 December 2020

Identification and spatial distribution of retinoids in the developing chick limb bud

1 reference

12 December 2020

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1 reference

12 December 2020

The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions

1 reference

12 December 2020

10.1101/CSHPERSPECT.A001339

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

20066096

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