Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development (Q28831339)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693838%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Rae-Anne Hardie

2

1 reference

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3 June 2020

Andrew J. Hoy

3

1 reference

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3 June 2020

Martin Sadowski

7

1 reference

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3 June 2020

Justin J L Wong

11

1 reference

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3 June 2020

Natalia Pinello

13

1 reference

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3 June 2020

Charles G. Bailey

18

1 reference

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3 June 2020

Jeff Holst

21

1 reference

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3 June 2020

17

Colleen C Nelson

1 reference

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3 June 2020

12

Cynthia Metierre

1 reference

3 June 2020

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author name string

Michelle van Geldermalsen

4

1 reference

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3 June 2020

Dadi Gao

5

1 reference

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3 June 2020

Ladan Fazli

6

1 reference

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3 June 2020

Seher Balaban

8

1 reference

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3 June 2020

Mark Schreuder

9

1 reference

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3 June 2020

Rajini Nagarajah

10

1 reference

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3 June 2020

Nicholas J Otte

14

1 reference

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3 June 2020

Melanie L Lehman

15

1 reference

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3 June 2020

Martin Gleave

16

1 reference

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3 June 2020

William Ritchie

19

1 reference

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3 June 2020

John E J Rasko

20

1 reference

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3 June 2020

language of work or name

English

0 references

publication date

July 2015

0 references

published in

Journal of Pathology

1 reference

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3 June 2020

volume

236

1 reference

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3 June 2020

issue

3

1 reference

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3 June 2020

page(s)

278-289

1 reference

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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

3 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Bidirectional transport of amino acids regulates mTOR and autophagy

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Control of glutamine metabolism by the tumor suppressor Rb.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Targeting the ATF4 pathway in cancer therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Ngamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Targeting glutamine transport to suppress melanoma cell growth.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Glutaminolysis activates Rag-mTORC1 signaling.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Expression of neutral amino acid transporter ASCT2 in human prostate

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4973854

Clinicopathological significance of ASC amino acid transporter-2 expression in pancreatic ductal carcinoma

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25693838

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PATH.4518

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693838%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693838%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

25693838

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25693838%20AND%20SRC:MED&resulttype=core&format=json