Peroxisome proliferator-activated receptor delta (Q29519436)

Nuclear hormone receptor-like domain superfamily

1 reference

Zinc finger, NHR/GATA-type

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

transcription cis-regulatory region binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

DNA binding

DNA-binding transcription factor activity

Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

steroid hormone receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

1 reference

14 February 2019

transcription coactivator activity

1 reference

14 February 2019

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

nuclear receptor activity

Evidence for the presence of both peroxisome proliferator-activated receptors alpha and beta in the rat spinal cord

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

fatty acid binding

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

1 reference

14 February 2019

nuclear receptor coactivator activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

signaling receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

1 reference

14 February 2019

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

NF-kappaB binding

IPI

1 reference

14 February 2019

Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

IPI

linoleic acid binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

14 February 2019

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

RNA polymerase II transcription regulator complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

biological process

placenta development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

proteoglycan metabolic process

1 reference

14 February 2019

Agonists of peroxisome proliferators-activated receptors (PPAR) alpha, beta/delta or gamma reduce transforming growth factor (TGF)-beta-induced proteoglycans' production in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

1 reference

14 February 2019

fatty acid metabolic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

fatty acid beta-oxidation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

vitamin A metabolic process

1 reference

14 February 2019

PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

multicellular organism development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

heart development

1 reference

14 February 2019

Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

axon ensheathment

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

phospholipid biosynthetic process

1 reference

14 February 2019

PPARdelta and its activator PGI2 are reduced in diabetic embryopathy: involvement of PPARdelta activation in lipid metabolic and signalling pathways in rat embryo early organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

mRNA transcription

1 reference

14 February 2019

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

response to glucose

1 reference

14 February 2019

Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

hormone-mediated signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of cholesterol storage

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

response to activity

1 reference

14 February 2019

Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

regulation of skeletal muscle satellite cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of smooth muscle cell migration

1 reference

14 February 2019

PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

fatty acid transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

regulation of lipid metabolic process

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

fatty acid oxidation

1 reference

14 February 2019

Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of cell growth

1 reference

14 February 2019

Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

intracellular receptor signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

cell-substrate adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of insulin secretion

1 reference

14 February 2019

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of collagen biosynthetic process

1 reference

14 February 2019

PPARbeta/delta activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

response to vitamin A

1 reference

14 February 2019

Effect of nutritional vitamin A deficiency on lipid metabolism in the rat heart: Its relation to PPAR gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

response to lipid

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

wound healing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of apoptotic process

1 reference

14 February 2019

Peroxisome proliferator-activated receptor delta (PPARdelta) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

steroid hormone mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of skeletal muscle tissue regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

keratinocyte proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

regulation of fat cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of myoblast differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of epidermis development

1 reference

14 February 2019

PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

decidualization

1 reference

14 February 2019

Differential expression of peroxisome proliferator-activated receptor delta at implantation sites and in decidual cells of rat uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of smooth muscle cell proliferation

1 reference

14 February 2019

PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of epithelial cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of inflammatory response

keratinocyte migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

adipose tissue development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

cellular response to lipopolysaccharide

1 reference

14 February 2019

Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

cellular response to hypoxia

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

apoptotic signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

negative regulation of pri-miRNA transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

positive regulation of myoblast proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99ND3

nuclear hormone receptor-type zinc finger

has part(s)

1 reference

Nuclear hormone receptor, ligand-binding domain

1 reference