The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth (Q29547680)

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scientific article (publication date: 13 March 2008)

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English	The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth	scientific article (publication date: 13 March 2008)

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Europe PubMed Central

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18337823

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title

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth (English)

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Europe PubMed Central

PubMed publication ID

18337823

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author

Heather R Christofk

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1

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Europe PubMed Central

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18337823

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4 January 2020

Mark D Fleming

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7

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18337823

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4 January 2020

Stuart Schreiber

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8

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Stuart L Schreiber

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Europe PubMed Central

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18337823

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4 January 2020

author name string

Matthew G Vander Heiden

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2

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18337823

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4 January 2020

Marian H Harris

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3

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18337823

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4 January 2020

Arvind Ramanathan

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4

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18337823

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4 January 2020

Robert E Gerszten

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5

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18337823

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4 January 2020

Ru Wei

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6

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18337823

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4 January 2020

Lewis C Cantley

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9

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18337823

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4 January 2020

language of work or name

English

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publication date

1 March 2008

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18337823

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4 January 2020

published in

Nature

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PubMed

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18337823

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23 April 2017

stated in

Europe PubMed Central

PubMed publication ID

18337823

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337823%20AND%20SRC:MED&resulttype=core&format=json

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4 January 2020

volume

452

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23 April 2017

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Europe PubMed Central

PubMed publication ID

18337823

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337823%20AND%20SRC:MED&resulttype=core&format=json

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4 January 2020

issue

7184

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23 April 2017

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Europe PubMed Central

PubMed publication ID

18337823

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337823%20AND%20SRC:MED&resulttype=core&format=json

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4 January 2020

page(s)

230-233

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18337823

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4 January 2020

cites work

On the Origin of Cancer Cells

1 reference

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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Pyruvate kinase type M2 and its role in tumor growth and spreading

1 reference

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

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https://api.crossref.org/works/10.1038%2FNATURE06734

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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7 January 2021

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Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

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7 January 2021

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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7 January 2021

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Why do cancers have high aerobic glycolysis?

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

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7 January 2021

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Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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inferred from DOI database lookup

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate

1 reference

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Crossref

reference URL

https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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Ras transformation requires metabolic control by 6-phosphofructo-2-kinase

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Crossref

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https://api.crossref.org/works/10.1038%2FNATURE06734

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7 January 2021

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Growth factors can influence cell growth and survival through effects on glucose metabolism

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Metabolomic identification of novel biomarkers of myocardial ischemia

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7 January 2021

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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

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Genome-scale loss-of-function screening with a lentiviral RNAi library

1 reference

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7 January 2021

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Identifiers

DOI

10.1038/NATURE06734

3 references

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PubMed

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18337823

retrieved

23 April 2017

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

92218

stated in

Europe PubMed Central

PubMed publication ID

18337823

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337823%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 January 2020

Dimensions Publication ID

1025803113

0 references

OpenCitations bibliographic resource ID

92218

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

92218

PubMed publication ID

18337823

3 references

stated in

PubMed

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=18337823

retrieved

23 April 2017

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

92218

stated in

Europe PubMed Central

PubMed publication ID

18337823

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18337823%20AND%20SRC:MED&resulttype=core&format=json

retrieved

4 January 2020

ResearchGate publication ID

5514125

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