Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation (Q29615366)

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17 January 2020

title

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation (English)

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30 April 2017

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17 January 2020

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17 January 2020

Omar Abdel-Wahab

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Patrick S. Ward

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Elisabeth Paietta

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Craig B Thompson

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17 January 2020

author name string

Chao Lu

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Jay Patel

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Alan Shih

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Yushan Li

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Neha Bhagwat

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Aparna Vasanthakumar

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Hugo F Fernandez

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Martin S Tallman

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Zhuoxin Sun

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Kristy Wolniak

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Justine K Peeters

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Wei Liu

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Sung E Choe

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Valeria R Fantin

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Jonathan D Licht

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Ruud Delwel

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Peter J M Valk

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Ross L Levine

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Ari Melnick

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30 April 2017

publication date

9 December 2010

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volume

18

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17 January 2020

issue

6

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17 January 2020

page(s)

553-567

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Comprehensive methylome map of lineage commitment from haematopoietic progenitors

17 January 2020

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Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

30 April 2017

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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

30 April 2017

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

30 April 2017

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30 April 2017

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30 April 2017

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30 April 2017

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

30 April 2017

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A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a

30 April 2017

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Comparative isoschizomer profiling of cytosine methylation: the HELP assay

30 April 2017

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

30 April 2017

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30 April 2017

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30 April 2017

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30 April 2017

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30 April 2017

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3 June 2018

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3 June 2018

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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

3 June 2018

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IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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26 November 2018

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26 November 2018

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26 November 2018

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10.1016/J.CCR.2010.11.015

26 November 2018

Identifiers

DOI

3 references

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30 April 2017

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17 January 2020

1 reference

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3 references

30 April 2017

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17 January 2020

PubMed publication ID

3 references

30 April 2017