Somatic generation of antibody diversity (Q29616439)

Europe PubMed Central

title

Somatic generation of antibody diversity (English)

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30 April 2017

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Tonegawa S

1

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30 April 2017

language of work or name

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30 April 2017

publication date

14 April 1983

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30 April 2017

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30 April 2017

volume

302

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30 April 2017

issue

5909

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30 April 2017

page(s)

575-81

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THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION

30 April 2017

cites work

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7 January 2021

Immunological speculations

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7 January 2021

The somatic generation of immune recognition

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7 January 2021

Selection under a somatic model

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7 January 2021

Amino acid sequence studies with Bence-Jones proteins

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7 January 2021

An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity

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7 January 2021

Three-dimensional structure of immunoglobulins

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7 January 2021

The molecular basis of antibody formation: a paradox

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7 January 2021

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

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7 January 2021

Cloning of an immunoglobulin variable region gene from mouse embryo

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7 January 2021

Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart

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7 January 2021

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain

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7 January 2021

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7 January 2021

Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA

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7 January 2021

A complete immunoglobulin gene is created by somatic recombination

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7 January 2021

DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats

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7 January 2021

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

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7 January 2021

The arrangement and rearrangement of antibody genes

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7 January 2021

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

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7 January 2021

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

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7 January 2021

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene

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7 January 2021

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.

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7 January 2021

Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity

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7 January 2021

Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells

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7 January 2021

Rat kappa-chain J-segment genes: Two recent gene duplications separate rat and mouse

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7 January 2021

Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region

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7 January 2021

Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains

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7 January 2021

Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse

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7 January 2021

Chromosomal assignment of the mouse kappa light chain genes

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7 January 2021

Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.

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7 January 2021

Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains

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7 January 2021

Organization of four mouse lambda light chain immunoglobulin genes

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7 January 2021

DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes

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7 January 2021

Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression

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7 January 2021

Characterization of a mouse DNA clone containing an immunoglobulin variable region gene

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7 January 2021

Variability in the Lambda Light Chain Sequences of Mouse Antibody

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7 January 2021

Identification of a third type of lambda light chain in mouse immunoglobulins

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7 January 2021

Unusual association of V, J and C regions in a mouse immunoglobulin lambda chain

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7 January 2021

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7 January 2021

Identical 3' non-coding sequences in five mouse Ig kappa chain mRNAs favour a unique C kappa gene

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7 January 2021

Rearrangement of genetic information may produce immunoglobulin diversity

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7 January 2021

Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangements in heavy chain V-region gene segments

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7 January 2021

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

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7 January 2021

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

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7 January 2021

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments

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7 January 2021

Diversity of germ-line immunoglobulin VH genes

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7 January 2021

Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity

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7 January 2021

Mouse immunoglobulin D: messenger RNA and genomic DNA sequences

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7 January 2021

Linkage of the four gamma subclass heavy chain genes

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7 January 2021

The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes

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7 January 2021

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

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7 January 2021

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

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7 January 2021

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions

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7 January 2021

Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain

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7 January 2021

Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways

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7 January 2021

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends

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7 January 2021

Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms

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7 January 2021

Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes

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7 January 2021

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

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7 January 2021

Exon shuffling generates an immunoglobulin heavy chain gene

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Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism

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7 January 2021

Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes

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Immunoglobulin heavy-chain constant-region genes

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7 January 2021

The joining of V and J gene segments creates antibody diversity

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7 January 2021

Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma

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7 January 2021

Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene

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7 January 2021

Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene

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7 January 2021

RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene

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7 January 2021

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

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7 January 2021

Allelic exclusion and nonproductive immunoglobulin gene rearrangements

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7 January 2021

Somatic Changes in the Content and Context of Immunoglobulin Genes

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7 January 2021

Recombined flanks of the variable and joining segments of immunoglobulin genes

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7 January 2021

DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus

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7 January 2021

Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments

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7 January 2021

A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments

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7 January 2021

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

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7 January 2021

A novel type of aberrant recombination in immunoglobulin genes and its implications for V-J joining mechanism

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7 January 2021

A possible genetic basis for specific pattern in antibody.

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7 January 2021

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7 January 2021

Origin of Antibody Variation

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7 January 2021

Mechanism of antibody diversity: germ line basis for variability

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7 January 2021

Somatic translocation of antibody genes

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7 January 2021

Crossover Model of Antibody Variability

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7 January 2021

Antibody variability. Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability

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7 January 2021

Genetic Control of Antibody Variable Regions

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7 January 2021

Somatic mutation of immunoglobulin light-chain variable-region genes

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7 January 2021

Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins

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7 January 2021

Mechanisms of antibody diversity: Multiple genes encode structurally related mouse κ variable regions

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7 January 2021

Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity

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7 January 2021

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

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7 January 2021

A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody

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7 January 2021

Antibody diversity: somatic hypermutation of rearranged VH genes

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7 January 2021

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region

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7 January 2021

Gene conversion: some implications for immunoglobulin genes

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7 January 2021

Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.

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7 January 2021

Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse

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7 January 2021

Dual expression of λ genes in the MOPC-315 plasmacytoma

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7 January 2021

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

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7 January 2021

Cloning and sequence of the cDNA corresponding to the variable region of immunoglobulin heavy chain MPC11

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7 January 2021

Two Types of DNA Rearrangements in Immunoglobulin Genes

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7 January 2021

Organization and reorganization of immunoglobulin heavy-chain genes

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7 January 2021

Immunoglobulin gene rearrangements in normal mouse B cells

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7 January 2021

Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin

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7 January 2021

Somatic mutation gains its place among the generators of diversity

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7 January 2021

Identifiers

DOI

10.1038/302575A0

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1025246621

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6300689

PubMed publication ID

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017