Patched Dmel_CG2411 (Q29814411)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18502

Eukaryotic Sterol Transporter

1 reference

Transporter Classification Database ID

2.A.6.6.2

hierarchical database ID heuristic

2 October 2019

based on heuristic

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

transmembrane signaling receptor activity

1 reference

10 September 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

protein binding

3 references

9 May 2019

Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

Genetic and biochemical definition of the Hedgehog receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

hedgehog receptor activity

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

lipoprotein particle receptor activity

1 reference

9 May 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

smoothened binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

hedgehog receptor activity

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

hedgehog family protein binding

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

hedgehog receptor activity

Dual roles for patched in sequestering and transducing Hedgehog

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

phosphatidylinositol-4-phosphate binding

1 reference

9 May 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

cell component

cytoplasm

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

cilium

1 reference

9 May 2019

Cilia-mediated hedgehog signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

1 reference

9 May 2019

integral component of membrane

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

1 January 2018

endocytic vesicle

1 reference

9 May 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

fusome

1 reference

9 May 2019

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

perinuclear region of cytoplasm

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

3 references

9 May 2019

9 May 2019

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

basal plasma membrane

1 reference

9 May 2019

Cytoneme-mediated cell-cell contacts for Hedgehog reception.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

Bolwig's organ morphogenesis

biological process

1 reference

9 May 2019

Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

proteolysis

1 reference

7 November 2018

The sterol-sensing domain: multiple families, a unique role?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

receptor-mediated endocytosis

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

smoothened signaling pathway

Cholesterol metabolism and embryogenesis

6 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

21 June 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

1 reference

9 May 2019

regulation of mitotic cell cycle

1 reference

9 May 2019

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

segment polarity determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

1 reference

9 May 2019

axon guidance

1 reference

9 May 2019

Patched regulation of axon guidance is by specifying neural identity in the Drosophila nerve cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

peripheral nervous system development

1 reference

1 January 2018

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

eye-antennal disc morphogenesis

1 reference

9 May 2019

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

imaginal disc-derived wing morphogenesis

1 reference

9 May 2019

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

gonad development

1 reference

9 May 2019

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

embryonic pattern specification

1 reference

1 January 2018

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

anterior/posterior pattern specification

1 reference

10 September 2018

The sterol-sensing domain: multiple families, a unique role?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

dephosphorylation

1 reference

7 November 2018

The sterol-sensing domain: multiple families, a unique role?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

ovarian follicle cell development

1 reference

1 January 2018

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination of genital disc primordium

1 reference

9 May 2019

Allocation and specification of the genital disc precursor cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

germ-line stem cell division

1 reference

7 November 2018

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

regulation of apoptotic process

1 reference

9 May 2019

Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

anterior/posterior lineage restriction, imaginal disc

1 reference

9 May 2019

Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

wing disc anterior/posterior pattern formation

1 reference

9 May 2019

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

somatic stem cell division

1 reference

9 May 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

oogenesis

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

lipid homeostasis

1 reference

9 May 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

regulation of epithelial cell migration, open tracheal system

1 reference

9 May 2019

Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

ovarian follicle cell development

smoothened signaling pathway

7 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

Cholesterol metabolism and embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

smoothened signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

ovarian follicle cell development

1 reference

9 May 2019

Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

negative regulation of smoothened signaling pathway

Dual roles for patched in sequestering and transducing Hedgehog

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

9 May 2019

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

vesicle-mediated transport

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

endocytosis

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

has part(s)

Sterol-sensing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18502

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Transporter Classification Database ID

2.A.6.6.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database