Shaggy Dmel_CG2621 (Q29813806)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

9 references

8 April 2019

8 April 2019

Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

8 April 2019

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

protein binding

3 references

8 April 2019

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

The Drosophila circadian network is a seasonal timer

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

4 references

8 April 2019

8 April 2019

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

nucleoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

3 references

8 April 2019

8 April 2019

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

centrosome

Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

microtubule organizing center

HDA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

cell cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

neuromuscular junction

1 reference

8 April 2019

Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

female germline ring canal

1 reference

8 April 2019

Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

fusome

1 reference

8 April 2019

New components of the Drosophila fusome suggest it plays novel roles in signaling and transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

biological process

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

4 references

8 April 2019

8 April 2019

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

spindle organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

female meiotic nuclear division

1 reference

8 April 2019

Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

segment polarity determination

Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

heart development

1 reference

8 April 2019

Genetics of heart development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

rhythmic behavior

1 reference

8 April 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

olfactory learning

1 reference

8 April 2019

GSK-3/Shaggy regulates olfactory habituation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

chaeta morphogenesis

1 reference

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

imaginal disc-derived wing margin morphogenesis

1 reference

8 April 2019

The wingless signalling pathway and the patterning of the wing margin in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

entrainment of circadian clock

1 reference

8 April 2019

Serotonin modulates circadian entrainment in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

chaeta development

1 reference

8 April 2019

Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

regulation of proteolysis

1 reference

8 April 2019

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

pseudocleavage involved in syncytial blastoderm formation

1 reference

8 April 2019

Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

ovarian follicle cell development

1 reference

8 April 2019

Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

somatic stem cell population maintenance

1 reference

8 April 2019

Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

wing and notum subfield formation

1 reference

8 April 2019

Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

regulation of protein import into nucleus

1 reference

8 April 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

regulation of circadian rhythm

1 reference

8 April 2019

GSK-3/Shaggy regulates olfactory habituation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

negative regulation of JUN kinase activity

1 reference

8 April 2019

Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

locomotor rhythm

1 reference

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

positive regulation of protein catabolic process

1 reference

8 April 2019

Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

positive regulation of mitotic metaphase/anaphase transition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

negative regulation of smoothened signaling pathway

negative regulation of synaptic assembly at neuromuscular junction

1 reference

8 April 2019

Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

negative regulation of insulin receptor signaling pathway

1 reference

8 April 2019

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

habituation

1 reference

8 April 2019

GSK-3/Shaggy regulates olfactory habituation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

oogenesis

1 reference

8 April 2019

Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

synaptic assembly at neuromuscular junction

1 reference

8 April 2019

Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

1 reference

8 April 2019

regulation of microtubule cytoskeleton organization

1 reference

8 April 2019

Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

regulation of calcineurin-NFAT signaling cascade

1 reference

8 April 2019

Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

response to anesthetic

1 reference

8 April 2019

Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

negative regulation of canonical Wnt signaling pathway

The wingless signalling pathway and the patterning of the wing margin in Drosophila

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgut

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

8 April 2019

A nuclear function for armadillo/beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

IGI

8 April 2019

Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

positive regulation of proteolysis involved in cellular protein catabolic process

IGI

1 reference

8 April 2019

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18431