Phosphodiesterase 4D (Q21106795)

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

scaffold protein binding

1 reference

8 April 2019

PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

cAMP binding

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

beta-2 adrenergic receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

protein binding

3 references

10 September 2018

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

phosphoric diester hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

enzyme binding

1 reference

8 April 2019

Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

ubiquitin protein ligase binding

1 reference

21 June 2018

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

transmembrane transporter binding

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

3',5'-cyclic-AMP phosphodiesterase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

6 references

10 September 2018

10 September 2018

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

3',5'-cyclic-AMP phosphodiesterase activity

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

protein binding

A proteome-scale map of the human interactome network

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

transmembrane transporter binding

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

ATPase binding

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

centrosome

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

microtubule organizing center

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

apical plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

cytosol

establishment of endothelial barrier

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

positive regulation of interleukin-5 production

1 reference

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

human ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

regulation of signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

positive regulation of interferon-gamma production

1 reference

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

neutrophil chemotaxis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

positive regulation of interleukin-2 production

1 reference

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

regulation of cell communication by electrical coupling involved in cardiac conduction

IC

1 reference

8 April 2019

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

adrenergic receptor signaling pathway

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

cellular response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

T cell receptor signaling pathway

1 reference

8 April 2019

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

IC

cAMP-mediated signaling

NAS

1 reference

8 April 2019

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

cellular response to cAMP

NAS

1 reference

21 June 2018

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

leukocyte migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

7 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

31 October 2017

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

31 October 2017

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

31 October 2017

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

31 October 2017

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

cellular response to epinephrine stimulus

2 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

21 June 2018

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

regulation of cardiac muscle cell contraction

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

2 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

1 reference

8 April 2019

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

5 June 2018

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

negative regulation of cAMP-mediated signaling

1 reference

10 September 2018

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499

1 reference

10 September 2018

cellular response to epinephrine stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

negative regulation of cAMP-mediated signaling

regulation of cardiac muscle cell contraction

Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5260

English

3'5'-cyclic nucleotide phosphodiesterase, conserved site

17 August 2016

has part(s)

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

HD/PDEase domain

1 reference

Identifiers

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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