Protein phosphatase 2 regulatory subunit Balpha (Q21114998)

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mammalian protein found in Homo sapiens

• PPP2R2A
• protein phosphatase 2, regulatory subunit B, alpha
• PP2A subunit B isoform PR55-alpha
• PP2A subunit B isoform alpha
• PP2A subunit B isoform B55-alpha
• serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
• PP2A subunit B isoform R2-alpha

edit

Language	Label	Description	Also known as
English	Protein phosphatase 2 regulatory subunit Balpha	mammalian protein found in Homo sapiens	PPP2R2A protein phosphatase 2, regulatory subunit B, alpha PP2A subunit B isoform PR55-alpha PP2A subunit B isoform alpha PP2A subunit B isoform B55-alpha serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PP2A subunit B isoform R2-alpha

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P63151

part of

WD40/YVTN repeat-like-containing domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P63151

WD40-repeat-containing domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P63151

Protein phosphatase 2A regulatory subunit PR55

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P63151

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein phosphatase 2A regulatory subunit PR55, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P63151

encoded by

PPP2R2A

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P63151

molecular function

protein binding

determination method or standard

IPI

19 references

retrieved

8 April 2019

stated in

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

HSF1 transcriptional activity is modulated by IER5 and PP2A/B55

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

FAM122A, a new endogenous inhibitor of protein phosphatase 2A

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

The tumor suppressor PP2A Abeta regulates the RalA GTPase

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

CIP2A inhibits PP2A in human malignancies

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

retrieved

8 April 2019

stated in

PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IPI

protein serine/threonine phosphatase activity

determination method or standard

IDA

TAS

2 references

retrieved

16 July 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

TAS

retrieved

16 July 2018

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IDA

protein phosphatase regulator activity

determination method or standard

IEA

TAS

2 references

retrieved

8 April 2019

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

protein-containing complex binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

tau protein binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

protein phosphatase 2A binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

protein serine/threonine phosphatase activity

determination method or standard

IBA

IDA

TAS

3 references

retrieved

10 September 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

TAS

retrieved

10 September 2018

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IDA

retrieved

10 September 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IBA

protein serine/threonine phosphatase activity

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IBA

cell component

nucleoplasm

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

TAS

protein phosphatase type 2A complex

determination method or standard

IDA

IEA

3 references

retrieved

16 July 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IEA

retrieved

16 July 2018

stated in

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IDA

retrieved

16 July 2018

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IDA

cytosol

determination method or standard

IBA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

TAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IBA

synapse

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

glutamatergic synapse

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

protein phosphatase type 2A complex

determination method or standard

IBA

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

retrieved

8 April 2019

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IDA

retrieved

8 April 2019

stated in

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IBA

biological process

response to morphine

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

G2/M transition of mitotic cell cycle

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

TAS

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

TAS

protein dephosphorylation

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

GOA

curator

UniProt

UniProt protein ID

P63151

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IDA

mitotic cell cycle

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IBA

peptidyl-serine dephosphorylation

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IBA

developmental process

determination method or standard

IBA

1 reference

retrieved

16 July 2018

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63151&geneProductId=UniProtKB:P63151

determination method or standard

IBA

regulation of phosphoprotein phosphatase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

IEA

mitotic nuclear membrane reassembly

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63151

determination method or standard

TAS

has part(s)

WD40 repeat

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P63151

Protein phosphatase 2A regulatory subunit PR55, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P63151

Identifiers

RefSeq protein ID

NP_001171062

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

NP_002708

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_005273616

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_005273617

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_011542867

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_011542868

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_011542869

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_011542870

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_011542871

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_024302954

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

XP_024302955

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5520

UniProt protein ID

P63151

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P63151

Ensembl protein ID

ENSP00000325074

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000325074

ENSP00000370113

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000370113

ENSP00000428164

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000428164

ENSP00000428165

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000428165

ENSP00000428542

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000428542

ENSP00000428705

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000428705

ENSP00000428800

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000428800

ENSP00000429279

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000429279

ENSP00000430320

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000430320

ENSP00000499441

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000499441

ENSP00000499648

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000499648

PDB structure ID

3DW8

1 reference

stated in

UniProt

UniProt protein ID

P63151

retrieved

4 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

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Multilingual sites(0 entries)

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