RAB27B, member RAS oncogene family (Q21115772)

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mammalian protein found in Homo sapiens

• RAB27B
• C25KG
• ras-related protein Rab-27B

edit

Language	Label	Description	Also known as
English	RAB27B, member RAS oncogene family	mammalian protein found in Homo sapiens	RAB27B C25KG ras-related protein Rab-27B

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O00194

part of

small GTPase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O00194

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O00194

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O00194

encoded by

RAB27B

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O00194

molecular function

nucleotide binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

protein domain specific binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IPI

GDP binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IDA

GTP binding

determination method or standard

IDA

ISS

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

8 April 2019

stated in

Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IDA

myosin V binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IPI

protein binding

determination method or standard

IPI

3 references

retrieved

8 April 2019

stated in

Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IPI

retrieved

8 April 2019

stated in

TLR4-mediated expulsion of bacteria from infected bladder epithelial cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IPI

GTPase activity

determination method or standard

ISS

IEA

3 references

retrieved

17 October 2017

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

ISS

retrieved

17 October 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IEA

GTPase activity

determination method or standard

IBA

IEA

ISS

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

cell component

Golgi apparatus

determination method or standard

IEA

1 reference

retrieved

17 October 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IEA

multivesicular body membrane

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Rab27a and Rab27b control different steps of the exosome secretion pathway

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IDA

secretory granule membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

melanosome

determination method or standard

IDA

1 reference

retrieved

17 October 2017

stated in

Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IDA

secretory granule

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

zymogen granule membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

apical plasma membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

Golgi stack

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Rab27a and Rab27b control different steps of the exosome secretion pathway

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IDA

trans-Golgi network transport vesicle

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Rab27a and Rab27b control different steps of the exosome secretion pathway

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IDA

extracellular exosome

determination method or standard

IDA

3 references

retrieved

17 October 2017

stated in

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IDA

retrieved

17 October 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IDA

retrieved

17 October 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IDA

plasma membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

TAS

platelet dense granule membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

TAS

anchored component of synaptic vesicle membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

Golgi apparatus

determination method or standard

IBA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

melanosome

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

extracellular exosome

determination method or standard

HDA

2 references

retrieved

8 April 2019

stated in

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

HDA

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

HDA

axon cytoplasm

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

biological process

multivesicular body sorting pathway

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Rab27a and Rab27b control different steps of the exosome secretion pathway

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IMP

regulation of exocytosis

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

melanosome transport

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

positive regulation of exocytosis

determination method or standard

IMP

1 reference

retrieved

17 October 2017

stated in

Rab27a and Rab27b control different steps of the exosome secretion pathway

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00194&geneProductId=UniProtKB:O00194

determination method or standard

IMP

platelet degranulation

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

TAS

intracellular protein transport

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

Rab protein signal transduction

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

positive regulation of exocytosis

determination method or standard

IBA

IMP

2 references

retrieved

8 April 2019

stated in

Rab27a and Rab27b control different steps of the exosome secretion pathway

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IMP

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IBA

synaptic vesicle endocytosis

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

anterograde axonal protein transport

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O00194

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00194

determination method or standard

IEA

has part(s)

small GTP-binding protein domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O00194

Identifiers

RefSeq protein ID

NP_004154

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

XP_006722581

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

XP_011524433

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

XP_016881402

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

XP_016881403

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

XP_024307000

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

NP_001362256

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

5874

UniProt protein ID

O00194

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O00194

Ensembl protein ID

ENSP00000262094

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000262094

ENSP00000465009

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000465009

ENSP00000468542

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000468542

PDB structure ID

2F7S

1 reference

stated in

UniProt

UniProt protein ID

O00194

retrieved

4 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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