Damage specific DNA binding protein 2 (Q21117438)

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mammalian protein found in Homo sapiens

damage-specific DNA binding protein 2, 48kDa
UV-DDB 2
UV-damaged DNA-binding protein 2
xeroderma pigmentosum group E protein
DDBb
DNA damage-binding protein 2
DDB2
Damage-specific DNA-binding protein 2
DDB p48 subunit

Language	Label	Description	Also known as
English	Damage specific DNA binding protein 2	mammalian protein found in Homo sapiens	damage-specific DNA binding protein 2, 48kDa UV-DDB 2 UV-damaged DNA-binding protein 2 xeroderma pigmentosum group E protein DDBb DNA damage-binding protein 2 DDB2 Damage-specific DNA-binding protein 2 DDB p48 subunit

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92466

DNA damage-binding protein 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92466

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92466

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ubiquitin-protein transferase activity

determination method or standard

1 reference

8 April 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

protein binding

determination method or standard

11 references

8 April 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

damaged DNA binding

determination method or standard

3 references

24 April 2018

Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92466&geneProductId=UniProtKB:Q92466

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92466&geneProductId=UniProtKB:Q92466

determination method or standard

24 April 2018

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92466&geneProductId=UniProtKB:Q92466

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

8 April 2019

Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

damaged DNA binding

determination method or standard

4 references

8 April 2019

Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

ubiquitin-protein transferase activity

determination method or standard

protein-containing complex binding

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

Cul4B-RING E3 ubiquitin ligase complex

determination method or standard

1 reference

8 April 2019

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

protein-containing complex

determination method or standard

1 reference

8 April 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

determination method or standard

3 references

Cul4B-RING E3 ubiquitin ligase complex

determination method or standard

protein-containing complex

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

biological process

nucleotide-excision repair

determination method or standard

1 reference

8 April 2019

Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

pyrimidine dimer repair

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

nucleotide-excision repair, DNA damage recognition

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

histone H2A monoubiquitination

determination method or standard

1 reference

8 April 2019

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

protein polyubiquitination

determination method or standard

1 reference

8 April 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

global genome nucleotide-excision repair

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

protein ubiquitination

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

nucleotide-excision repair, DNA incision

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

UV-damage excision repair

determination method or standard

1 reference

8 April 2019

Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

determination method or standard

1 reference

24 April 2018

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92466&geneProductId=UniProtKB:Q92466

determination method or standard

determination method or standard

3 references

protein autoubiquitination

determination method or standard

1 reference

8 April 2019

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

nucleotide-excision repair, DNA incision, 5'-to lesion

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

nucleotide-excision repair, preincision complex stabilization

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

nucleotide-excision repair, preincision complex assembly

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

protein deubiquitination

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

post-translational protein modification

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

protein polyubiquitination

determination method or standard

determination method or standard

response to UV-B

determination method or standard

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

histone H2A monoubiquitination

determination method or standard

protein autoubiquitination

determination method or standard

UV-damage excision repair

determination method or standard

nucleotide-excision repair, DNA duplex unwinding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

nucleotide-excision repair, DNA incision, 3'-to lesion

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

determination method or standard

4 references

8 April 2019

Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92466

determination method or standard

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92466

WD40 repeat, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92466

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000256996

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000256996

ENSP00000367863

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367863

ENSP00000367864

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367864

ENSP00000367866

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000367866

ENSP00000478411

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478411

ENSP00000478063

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478063

ENSP00000479196

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479196

ENSP00000479994

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479994

ENSP00000482080

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000482080

ENSP00000483718

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483718

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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