Nuclear factor, erythroid 2 like 2 (Q21119871)

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mammalian protein found in Homo sapiens
  • HEBP1
  • nuclear factor erythroid-derived 2-like 2
  • Nuclear factor, erythroid derived 2, like 2
  • NFE2L2
  • nuclear factor erythroid 2-related factor 2
  • NF-E2-Related Factor 2
  • NF-E2 p45-related factor 2
  • NRF2
  • NEH2
edit
Language Label Description Also known as
English
Nuclear factor, erythroid 2 like 2
mammalian protein found in Homo sapiens
  • HEBP1
  • nuclear factor erythroid-derived 2-like 2
  • Nuclear factor, erythroid derived 2, like 2
  • NFE2L2
  • nuclear factor erythroid 2-related factor 2
  • NF-E2-Related Factor 2
  • NF-E2 p45-related factor 2
  • NRF2
  • NEH2

Statements

molecular function
protein binding
determination method or standard
IPI
12 references
retrieved
8 April 2019
stated in
Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing
GOA
curator
UniProt
UniProt protein ID
Q16236
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
A protein domain-based interactome network for C. elegans early embryogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
8 references
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q16236
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
16 July 2018
stated in
Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q16236
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
16 July 2018
stated in
DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
16 July 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
16 July 2018
stated in
Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
16 July 2018
stated in
HO-1 underlies resistance of AML cells to TNF-induced apoptosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16236&geneProductId=UniProtKB:Q16236
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q16236
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
8 April 2019
stated in
Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q16236
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
8 April 2019
stated in
DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
8 April 2019
stated in
Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
8 April 2019
stated in
HO-1 underlies resistance of AML cells to TNF-induced apoptosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IC
IDA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3
GOA
curator
UniProt
UniProt protein ID
Q16236
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IMP
retrieved
8 April 2019
stated in
HO-1 underlies resistance of AML cells to TNF-induced apoptosis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IEA
retrieved
8 April 2019
stated in
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IDA
retrieved
8 April 2019
stated in
DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16236
determination method or standard
IC

Identifiers

 
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