Hypoxia inducible factor 1 subunit alpha inhibitor (Q21111638)

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mammalian protein found in Homo sapiens
  • factor inhibiting HIF-1
  • hypoxia-inducible factor asparagine hydroxylase
  • hypoxia-inducible factor 1-alpha inhibitor
  • HIF1AN
  • factor inhibiting HIF1
  • FIH-1
  • peptide-aspartate beta-dioxygenase
  • hypoxia inducible factor 1 alpha subunit inhibitor
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Language Label Description Also known as
English
Hypoxia inducible factor 1 subunit alpha inhibitor
mammalian protein found in Homo sapiens
  • factor inhibiting HIF-1
  • hypoxia-inducible factor asparagine hydroxylase
  • hypoxia-inducible factor 1-alpha inhibitor
  • HIF1AN
  • factor inhibiting HIF1
  • FIH-1
  • peptide-aspartate beta-dioxygenase
  • hypoxia inducible factor 1 alpha subunit inhibitor

Statements

molecular function
protein binding
determination method or standard
IPI
15 references
retrieved
8 April 2019
stated in
Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Network analysis of UBE3A/E6AP-associated proteins provides connections to several distinct cellular processes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
An empirical framework for binary interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
ankyrin repeat binding
determination method or standard
IBA
IPI
5 references
retrieved
8 April 2019
stated in
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IBA
cell component
biological process
peptidyl-asparagine hydroxylation
determination method or standard
IDA
IMP
5 references
retrieved
5 June 2018
stated in
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NWT6&geneProductId=UniProtKB:Q9NWT6
determination method or standard
IMP
retrieved
5 June 2018
stated in
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NWT6&geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
5 June 2018
stated in
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NWT6&geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
5 June 2018
stated in
Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NWT6&geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
5 June 2018
stated in
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NWT6&geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
peptidyl-asparagine hydroxylation
determination method or standard
IBA
IDA
IMP
6 references
retrieved
8 April 2019
stated in
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IMP
retrieved
8 April 2019
stated in
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
8 April 2019
stated in
Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
8 April 2019
stated in
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
8 April 2019
stated in
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
GOA
curator
UniProt
UniProt protein ID
Q9NWT6
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NWT6
determination method or standard
IBA

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21111638&oldid=2022946459"