SMG5 nonsense mediated mRNA decay factor (Q21124381)

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mammalian protein found in Homo sapiens

• smg-5 homolog, nonsense mediated mRNA decay factor
• EST1 telomerase component homolog B
• EST1-like protein B
• SMG5
• LPTS-RP1
• LPTS-interacting protein
• Est1p-like protein B
• ever shorter telomeres 1B
• LPTS interacting protein
• hSMG-5
• protein SMG5
• SMG-5 homolog

edit

Language	Label	Description	Also known as
English	SMG5 nonsense mediated mRNA decay factor	mammalian protein found in Homo sapiens	smg-5 homolog, nonsense mediated mRNA decay factor EST1 telomerase component homolog B EST1-like protein B SMG5 LPTS-RP1 LPTS-interacting protein Est1p-like protein B ever shorter telomeres 1B LPTS interacting protein hSMG-5 protein SMG5 SMG-5 homolog

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UPR3

part of

Tetratricopeptide-like helical domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UPR3

DNA/RNA-binding domain, Est1-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Telomerase activating protein Est1 family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UPR3

encoded by

SMG5

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UPR3

molecular function

protein phosphatase 2A binding

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IDA

histone deacetylase binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

protein binding

determination method or standard

IPI

5 references

retrieved

8 April 2019

stated in

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

GOA

curator

UniProt

UniProt protein ID

Q9UPR3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

retrieved

8 April 2019

stated in

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

retrieved

8 April 2019

stated in

An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

retrieved

8 April 2019

stated in

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

retrieved

8 April 2019

stated in

Functional conservation of the telomerase protein Est1p in humans

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

telomeric DNA binding

determination method or standard

IDA

1 reference

retrieved

27 March 2018

stated in

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IDA

ubiquitin protein ligase binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

ribonuclease activity

determination method or standard

IBA

1 reference

retrieved

10 September 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

ribonucleoprotein complex binding

determination method or standard

IBA

1 reference

retrieved

10 September 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

telomerase RNA binding

determination method or standard

IBA

IPI

2 references

retrieved

8 April 2019

stated in

An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IPI

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

telomeric DNA binding

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

cell component

cytoplasm

determination method or standard

IDA

IEA

2 references

retrieved

27 March 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UPR3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IEA

retrieved

27 March 2018

stated in

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IDA

cytosol

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

nucleus

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UPR3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IDA

telomerase holoenzyme complex

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

cytoplasm

determination method or standard

IBA

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UPR3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

biological process

regulation of dephosphorylation

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IMP

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

determination method or standard

TAS

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

retrieved

8 April 2019

stated in

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UPR3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IEA

mRNA export from nucleus

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

regulation of telomere maintenance

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IMP

regulation of telomere maintenance via telomerase

determination method or standard

TAS

1 reference

retrieved

10 September 2018

stated in

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

regulation of RNA stability

determination method or standard

IBA

1 reference

retrieved

10 September 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

RNA phosphodiester bond hydrolysis

determination method or standard

IEA

1 reference

retrieved

10 September 2018

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IEA

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

determination method or standard

IBA

IEA

TAS

4 references

retrieved

10 September 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

retrieved

10 September 2018

stated in

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

retrieved

10 September 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UPR3

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IEA

retrieved

10 September 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPR3&geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

telomere maintenance via telomerase

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

regulation of telomere maintenance via telomerase

determination method or standard

IBA

TAS

2 references

retrieved

8 April 2019

stated in

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

TAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPR3

determination method or standard

IBA

has part(s)

DNA/RNA-binding domain, Est1-type

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UPR3

PIN domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UPR3

Telomerase activating protein Est1

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UPR3

Identifiers

RefSeq protein ID

NP_001310543

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

23381

NP_001310544

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

23381

NP_001310545

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

23381

NP_001310546

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

23381

NP_056142

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

23381

UniProt protein ID

Q9UPR3

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UPR3

Ensembl protein ID

ENSP00000355261

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000355261

PDB structure ID

2HWY

1 reference

stated in

UniProt

UniProt protein ID

Q9UPR3

retrieved

4 August 2016

language of work or name

English

 

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21124381&oldid=2023003222"