Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (Q21120060)

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mammalian protein found in Homo sapiens

• MTHFD2
• bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
• NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase

edit

Language	Label	Description	Also known as
English	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	mammalian protein found in Homo sapiens	MTHFD2 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13995

part of

NAD(P)-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13995

encoded by

MTHFD2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13995

molecular function

oxidoreductase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

catalytic activity

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

hydrolase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

methenyltetrahydrofolate cyclohydrolase activity

determination method or standard

IEA

IBA

ISS

TAS

4 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

TAS

retrieved

1 January 2018

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

ISS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IBA

magnesium ion binding

determination method or standard

IDA

IMP

2 references

retrieved

8 April 2019

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IDA

methylenetetrahydrofolate dehydrogenase (NAD+) activity

determination method or standard

IDA

IEA

IMP

TAS

4 references

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

TAS

retrieved

26 September 2017

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

26 September 2017

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IDA

methylenetetrahydrofolate dehydrogenase (NADP+) activity

determination method or standard

IDA

IEA

IMP

3 references

retrieved

26 September 2017

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

26 September 2017

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IDA

phosphate ion binding

determination method or standard

IDA

IMP

2 references

retrieved

8 April 2019

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IDA

methylenetetrahydrofolate dehydrogenase (NAD+) activity

determination method or standard

IBA

IDA

IEA

IMP

TAS

5 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

TAS

retrieved

1 January 2018

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

1 January 2018

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IBA

methylenetetrahydrofolate dehydrogenase (NADP+) activity

determination method or standard

IBA

IDA

IEA

IMP

4 references

retrieved

8 April 2019

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IBA

methenyltetrahydrofolate cyclohydrolase activity

determination method or standard

IBA

IEA

ISS

3 references

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IBA

methylenetetrahydrofolate dehydrogenase (NAD+) activity

determination method or standard

IBA

IDA

IEA

IMP

4 references

retrieved

8 April 2019

stated in

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IMP

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IBA

cell component

mitochondrion

determination method or standard

IBA

ISS

IEA

4 references

retrieved

26 September 2017

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

ISS

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IBA

cytosol

determination method or standard

IBA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IBA

mitochondrial matrix

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

TAS

extracellular space

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IDA

extracellular space

determination method or standard

HDA

1 reference

retrieved

8 April 2019

stated in

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

HDA

mitochondrion

determination method or standard

IEA

ISS

2 references

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

biological process

metabolism

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

one-carbon metabolic process

determination method or standard

IBA

IEA

2 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IEA

retrieved

26 September 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IBA

tetrahydrofolate metabolic process

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13995&geneProductId=UniProtKB:P13995

determination method or standard

IDA

folic acid metabolic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

TAS

one-carbon metabolic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IEA

tetrahydrofolate interconversion

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IBA

tetrahydrofolate metabolic process

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

GOA

curator

UniProt

UniProt protein ID

P13995

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13995

determination method or standard

IBA

has part(s)

Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13995

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P13995

Identifiers

RefSeq protein ID

NP_006627

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

10797

XP_006711987

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

10797

UniProt protein ID

P13995

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P13995

Ensembl protein ID

ENSP00000377617

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000377617

ENSP00000386536

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386536

ENSP00000386542

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000386542

ENSP00000419067

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419067

ENSP00000419550

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419550

PDB structure ID

1ZN4

1 reference

stated in

Swiss-Prot

UniProt

retrieved

6 January 2016

reference URL

http://www.uniprot.org/uniprot/P13995.txt?version=168

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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